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6l1d

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Revision as of 11:37, 13 November 2019

Structure of human StAR-related lipid transfer protein 4

Structural highlights

6l1d is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	STARD4 (HUMAN)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[STAR4_HUMAN] Involved in the intracellular transport of cholesterol. Binds cholesterol or other sterols.^[1]

Publication Abstract from PubMed

The steroidogenic acute regulatory protein (StAR)-related lipid transfer domain-4 (STARD4) is a sterol-binding protein that is involved in cholesterol homeostasis by intracellular sterol transport. In this work, we determined the crystal structures of human STARD4 and its Omega1-loop mutant in apo forms at 1.95 and 1.7A resolutions, respectively. The structure of human STARD4 displays a conserved alpha-helix/beta-grip fold containing a deep hydrophobic pocket. The Omega1-loop which serves as a lid for the hydrophobic pocket has a closed conformation. The shape of the sterol-binding cavity in the closed form is not complementary to accommodate cholesterol, suggesting that a conformational change of the Omega1-loop is essential for sterol binding. The human STARD4 displayed sterol transfer activity between liposomes, and the mutations in the Omega1-loop and the hydrophobic wall abolished the transfer activity. This study confirms the structural conservation of the STARD4 subfamily proteins and the flexibility of the Omega1-loop and helix alpha4 required for sterol transport.

Structural analysis of human sterol transfer protein STARD4.,Tan L, Tong J, Chun C, Im YJ Biochem Biophys Res Commun. 2019 Oct 10. pii: S0006-291X(19)31941-2. doi:, 10.1016/j.bbrc.2019.10.054. PMID:31607485^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Rodriguez-Agudo D, Ren S, Wong E, Marques D, Redford K, Gil G, Hylemon P, Pandak WM. Intracellular cholesterol transporter StarD4 binds free cholesterol and increases cholesteryl ester formation. J Lipid Res. 2008 Jul;49(7):1409-19. doi: 10.1194/jlr.M700537-JLR200. Epub 2008, Apr 9. PMID:18403318 doi:http://dx.doi.org/10.1194/jlr.M700537-JLR200
↑ Tan L, Tong J, Chun C, Im YJ. Structural analysis of human sterol transfer protein STARD4. Biochem Biophys Res Commun. 2019 Oct 10. pii: S0006-291X(19)31941-2. doi:, 10.1016/j.bbrc.2019.10.054. PMID:31607485 doi:http://dx.doi.org/10.1016/j.bbrc.2019.10.054

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6l1d"

@@ Line 3: / Line 3: @@
 <StructureSection load='6l1d' size='340' side='right'caption='[[6l1d]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6l1d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L1D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6L1D FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6l1d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L1D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6L1D FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6l1d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l1d OCA], [http://pdbe.org/6l1d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6l1d RCSB], [http://www.ebi.ac.uk/pdbsum/6l1d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6l1d ProSAT]</span></td></tr>
+</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">STARD4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6l1d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l1d OCA], [http://pdbe.org/6l1d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6l1d RCSB], [http://www.ebi.ac.uk/pdbsum/6l1d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6l1d ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 21: / Line 22: @@
 __TOC__
 </StructureSection>
+[[Category: Human]]
 [[Category: Large Structures]]
 [[Category: Im, Y J]]

6l1d

From Proteopedia

Revision as of 11:37, 13 November 2019

Structure of human StAR-related lipid transfer protein 4

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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