2uvc

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[[Image:2uvc.gif|left|200px]]
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[[Image:2uvc.png|left|200px]]
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==Overview==
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{{ABSTRACT_17431175}}
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We report crystal structures of the 2.6-megadalton alpha6beta6 heterododecameric fatty acid synthase from Thermomyces lanuginosus at 3.1 angstrom resolution. The alpha and beta polypeptide chains form the six catalytic domains required for fatty acid synthesis and numerous expansion segments responsible for extensive intersubunit connections. Detailed views of all active sites provide insights into substrate specificities and catalytic mechanisms and reveal their unique characteristics, which are due to the integration into the multienzyme. The mode of acyl carrier protein attachment in the reaction chamber, together with the spatial distribution of active sites, suggests that iterative substrate shuttling is achieved by a relatively restricted circular motion of the carrier domain in the multifunctional enzyme.
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==About this Structure==
==About this Structure==
2UVC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermomyces_lanuginosus Thermomyces lanuginosus]. The following page contains interesting information on the relation of 2UVC with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb90_1.html Fatty Acid Synthase]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UVC OCA].
2UVC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermomyces_lanuginosus Thermomyces lanuginosus]. The following page contains interesting information on the relation of 2UVC with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb90_1.html Fatty Acid Synthase]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UVC OCA].
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==Reference==
 
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Structure of fungal fatty acid synthase and implications for iterative substrate shuttling., Jenni S, Leibundgut M, Boehringer D, Frick C, Mikolasek B, Ban N, Science. 2007 Apr 13;316(5822):254-61. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17431175 17431175]
 
[[Category: Fatty Acid Synthase]]
[[Category: Fatty Acid Synthase]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Substrate shuttling]]
[[Category: Substrate shuttling]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 30 13:51:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 18:24:05 2008''

Revision as of 15:24, 26 June 2008

Image:2uvc.png

Template:STRUCTURE 2uvc

CRYSTAL STRUCTURE OF FATTY ACID SYNTHASE COMPLEXED WITH NADP+ FROM THERMOMYCES LANUGINOSUS AT 3.1 ANGSTROM RESOLUTION. THIS FILE CONTAINS THE BETA SUBUNITS OF THE FATTY ACID SYNTHASE. THE ENTIRE CRYSTAL STRUCTURE CONSISTS OF ONE HETERODODECAMERIC FATTY ACID SYNTHASE AND IS DESCRIBED IN REMARK 400


Template:ABSTRACT 17431175

About this Structure

2UVC is a Single protein structure of sequence from Thermomyces lanuginosus. The following page contains interesting information on the relation of 2UVC with [Fatty Acid Synthase]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 18:24:05 2008

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