6hzu

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Current revision (09:03, 9 October 2024) (edit) (undo)
 
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<StructureSection load='6hzu' size='340' side='right'caption='[[6hzu]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='6hzu' size='340' side='right'caption='[[6hzu]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6hzu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HZU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HZU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6hzu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HZU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HZU FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GYQ:2-[4-[8-oxidanylidene-2-[(~{E})-(2-oxidanylidenepyridin-3-ylidene)amino]-7~{H}-purin-9-yl]cyclohexyl]ethanenitrile'>GYQ</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GYQ:2-[4-[8-oxidanylidene-2-[(~{E})-(2-oxidanylidenepyridin-3-ylidene)amino]-7~{H}-purin-9-yl]cyclohexyl]ethanenitrile'>GYQ</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hzu OCA], [https://pdbe.org/6hzu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hzu RCSB], [https://www.ebi.ac.uk/pdbsum/6hzu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hzu ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hzu OCA], [http://pdbe.org/6hzu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hzu RCSB], [http://www.ebi.ac.uk/pdbsum/6hzu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hzu ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/JAK1_HUMAN JAK1_HUMAN]] Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.
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[https://www.uniprot.org/uniprot/JAK1_HUMAN JAK1_HUMAN] Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6hzu" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6hzu" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Janus kinase 3D structures|Janus kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Non-specific protein-tyrosine kinase]]
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[[Category: Bach J]]
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[[Category: Bach, J]]
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[[Category: Blaesse M]]
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[[Category: Blaesse, M]]
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[[Category: Jestel A]]
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[[Category: Jestel, A]]
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[[Category: Lammens A]]
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[[Category: Lammens, A]]
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[[Category: Lozoya E]]
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[[Category: Lozoya, E]]
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[[Category: Segarra V]]
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[[Category: Segarra, V]]
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[[Category: Jak1]]
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[[Category: Janus kinase]]
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[[Category: Kinase domain]]
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[[Category: Protein binding]]
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[[Category: Proteros biostructures gmbh]]
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Current revision

HUMAN JAK1 IN COMPLEX WITH LASW1393

PDB ID 6hzu

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OCA

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