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1ik8
From Proteopedia
(Difference between revisions)
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<StructureSection load='1ik8' size='340' side='right'caption='[[1ik8]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''> | <StructureSection load='1ik8' size='340' side='right'caption='[[1ik8]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1ik8]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1ik8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bungarus_multicinctus Bungarus multicinctus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IK8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IK8 FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1hn7|1hn7]], [[1hoy|1hoy]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1hn7|1hn7]], [[1hoy|1hoy]]</div></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ik8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ik8 OCA], [https://pdbe.org/1ik8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ik8 RCSB], [https://www.ebi.ac.uk/pdbsum/1ik8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ik8 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/NXL1A_BUNMU NXL1A_BUNMU]] Binds with high affinity to muscular and neuronal (alpha-7, alpha-8, and alpha-9) nicotinic acetylcholine receptors. Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site. Blocks the extracellular increase of dopamine evoked by nicotine only at the higher dose (4.2 uM).<ref>PMID:9305882</ref> <ref>PMID:9840221</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 11:01, 4 August 2021
NMR structure of Alpha-Bungarotoxin
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