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1hkf

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Revision as of 10:50, 4 August 2021

The three dimensional structure of NK cell receptor Nkp44, a triggering partner in natural cytotoxicity

Structural highlights

1hkf is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Natural killer (NK) cells direct cytotoxicity against tumor or virally infected cells. NK cell activation depends on a fine balance between inhibitory and activating receptors. NKp44 is a cytotoxicity activating receptor composed of one Ig-like extracellular domain, a transmembrane segment, and a cytoplasmic domain. The 2.2 A crystal structure shows that the NKp44 Ig domain forms a saddle-shaped dimer, where a charged surface groove protrudes from the core structure in each subunit. NKp44 Ig domain disulfide bridge topology defines a new Ig structural subfamily. The data presented are a first step toward understanding the molecular basis for ligand recognition by natural cytotoxicity receptors, whose key role in the immune system is established, but whose cellular ligands are still elusive.

The three-dimensional structure of the human NK cell receptor NKp44, a triggering partner in natural cytotoxicity.,Cantoni C, Ponassi M, Biassoni R, Conte R, Spallarossa A, Moretta A, Moretta L, Bolognesi M, Bordo D Structure. 2003 Jun;11(6):725-34. PMID:12791260^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Cantoni C, Ponassi M, Biassoni R, Conte R, Spallarossa A, Moretta A, Moretta L, Bolognesi M, Bordo D. The three-dimensional structure of the human NK cell receptor NKp44, a triggering partner in natural cytotoxicity. Structure. 2003 Jun;11(6):725-34. PMID:12791260

1 Structural highlights
2 Evolutionary Conservation
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1hkf"

@@ Line 3: / Line 3: @@
 <StructureSection load='1hkf' size='340' side='right'caption='[[1hkf]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1hkf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HKF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HKF FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1hkf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HKF FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hkf OCA], [http://pdbe.org/1hkf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1hkf RCSB], [http://www.ebi.ac.uk/pdbsum/1hkf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1hkf ProSAT]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hkf OCA], [https://pdbe.org/1hkf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hkf RCSB], [https://www.ebi.ac.uk/pdbsum/1hkf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hkf ProSAT]</span></td></tr>
 </table>
 == Evolutionary Conservation ==

1hkf

From Proteopedia

Revision as of 10:50, 4 August 2021

The three dimensional structure of NK cell receptor Nkp44, a triggering partner in natural cytotoxicity

Structural highlights

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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