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1h7y

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Revision as of 10:46, 4 August 2021

Translationally Controlled Tumor-associated Protein p23fyp from Schizosaccharomyces pombe

Structural highlights

1h7y is a 1 chain structure with sequence from Cbs 356. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Related:	1h6q
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[TCTP_SCHPO] Involved in calcium binding and microtubule stabilization (By similarity). May be a guanine nucleotide-free chaperone (GFC).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The translationally controlled tumor-associated proteins (TCTPs) are a highly conserved and abundantly expressed family of eukaryotic proteins that are implicated in both cell growth and the human acute allergic response but whose intracellular biochemical function has remained elusive. We report here the solution structure of the TCTP from Schizosaccharomyces pombe, which, on the basis of sequence homology, defines the fold of the entire family. We show that TCTPs form a structural superfamily with the Mss4/Dss4 family of proteins, which bind to the GDP/GTP free form of Rab proteins (members of the Ras superfamily) and have been termed guanine nucleotide-free chaperones (GFCs). Mss4 also acts as a relatively inefficient guanine nucleotide exchange factor (GEF). We further show that the Rab protein binding site on Mss4 coincides with the region of highest sequence conservation in the TCTP family. This is the first link to any other family of proteins that has been established for the TCTP family and suggests the presence of a GFC/GEF at extremely high abundance in eukaryotic cells.

Structure of TCTP reveals unexpected relationship with guanine nucleotide-free chaperones.,Thaw P, Baxter NJ, Hounslow AM, Price C, Waltho JP, Craven CJ Nat Struct Biol. 2001 Aug;8(8):701-4. PMID:11473261^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Thaw P, Baxter NJ, Hounslow AM, Price C, Waltho JP, Craven CJ. Structure of TCTP reveals unexpected relationship with guanine nucleotide-free chaperones. Nat Struct Biol. 2001 Aug;8(8):701-4. PMID:11473261 doi:10.1038/90415

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1h7y"

@@ Line 3: / Line 3: @@
 <StructureSection load='1h7y' size='340' side='right'caption='[[1h7y]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1h7y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H7Y FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1h7y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H7Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H7Y FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1h6q|1h6q]]</td></tr>
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1h6q|1h6q]]</div></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7y OCA], [http://pdbe.org/1h7y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1h7y RCSB], [http://www.ebi.ac.uk/pdbsum/1h7y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1h7y ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h7y OCA], [https://pdbe.org/1h7y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h7y RCSB], [https://www.ebi.ac.uk/pdbsum/1h7y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h7y ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/TCTP_SCHPO TCTP_SCHPO]] Involved in calcium binding and microtubule stabilization (By similarity). May be a guanine nucleotide-free chaperone (GFC).
+[[https://www.uniprot.org/uniprot/TCTP_SCHPO TCTP_SCHPO]] Involved in calcium binding and microtubule stabilization (By similarity). May be a guanine nucleotide-free chaperone (GFC).
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]

1h7y

From Proteopedia

Revision as of 10:46, 4 August 2021

Translationally Controlled Tumor-associated Protein p23fyp from Schizosaccharomyces pombe

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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