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1ig7

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Revision as of 11:00, 4 August 2021

Msx-1 Homeodomain/DNA Complex Structure

Structural highlights

1ig7 is a 3 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[MSX1_MOUSE] Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis.^[1] ^[2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The Msx-1 homeodomain protein plays a crucial role in craniofacial, limb, and nervous system development. Homeodomain DNA-binding domains are comprised of 60 amino acids that show a high degree of evolutionary conservation. We have determined the structure of the Msx-1 homeodomain complexed to DNA at 2.2 A resolution. The structure has an unusually well-ordered N-terminal arm with a unique trajectory across the minor groove of the DNA. DNA specificity conferred by bases flanking the core TAAT sequence is explained by well ordered water-mediated interactions at Q50. Most interactions seen at the TAAT sequence are typical of the interactions seen in other homeodomain structures. Comparison of the Msx-1-HD structure to all other high resolution HD-DNA complex structures indicate a remarkably well-conserved sphere of hydration between the DNA and protein in these complexes.

Crystal structure of the Msx-1 homeodomain/DNA complex.,Hovde S, Abate-Shen C, Geiger JH Biochemistry. 2001 Oct 9;40(40):12013-21. PMID:11580277^[3]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Davidson DR, Crawley A, Hill RE, Tickle C. Position-dependent expression of two related homeobox genes in developing vertebrate limbs. Nature. 1991 Aug 1;352(6334):429-31. PMID:1677742 doi:http://dx.doi.org/10.1038/352429a0
↑ Catron KM, Zhang H, Marshall SC, Inostroza JA, Wilson JM, Abate C. Transcriptional repression by Msx-1 does not require homeodomain DNA-binding sites. Mol Cell Biol. 1995 Feb;15(2):861-71. PMID:7823952
↑ Hovde S, Abate-Shen C, Geiger JH. Crystal structure of the Msx-1 homeodomain/DNA complex. Biochemistry. 2001 Oct 9;40(40):12013-21. PMID:11580277

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ig7"

@@ Line 3: / Line 3: @@
 <StructureSection load='1ig7' size='340' side='right'caption='[[1ig7]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1ig7]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IG7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IG7 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1ig7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IG7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IG7 FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ig7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ig7 OCA], [http://pdbe.org/1ig7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ig7 RCSB], [http://www.ebi.ac.uk/pdbsum/1ig7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ig7 ProSAT]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ig7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ig7 OCA], [https://pdbe.org/1ig7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ig7 RCSB], [https://www.ebi.ac.uk/pdbsum/1ig7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ig7 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/MSX1_MOUSE MSX1_MOUSE]] Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis.<ref>PMID:1677742</ref> <ref>PMID:7823952</ref>
+[[https://www.uniprot.org/uniprot/MSX1_MOUSE MSX1_MOUSE]] Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis.<ref>PMID:1677742</ref> <ref>PMID:7823952</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]

1ig7

From Proteopedia

Revision as of 11:00, 4 August 2021

Msx-1 Homeodomain/DNA Complex Structure

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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