This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1n38

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1n38.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1n38.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1n38| PDB=1n38 | SCENE= }}
{{STRUCTURE_1n38| PDB=1n38 | SCENE= }}
-
'''reovirus polymerase lambda3 elongation complex with one phosphodiester bond formed'''
+
===reovirus polymerase lambda3 elongation complex with one phosphodiester bond formed===
-
==Overview==
+
<!--
-
The reovirus polymerase and those of other dsRNA viruses function within the confines of a protein capsid to transcribe the tightly packed dsRNA genome segments. The crystal structure of the reovirus polymerase, lambda3, determined at 2.5 A resolution, shows a fingers-palm-thumb core, similar to those of other viral polymerases, surrounded by major N- and C-terminal elaborations, which create a cage-like structure, with four channels leading to the catalytic site. This "caged" polymerase has allowed us to visualize the results of several rounds of RNA polymerization directly in the crystals. A 5' cap binding site on the surface of lambda3 suggests a template retention mechanism by which attachment of the 5' end of the plus-sense strand facilitates insertion of the 3' end of the minus-sense strand into the template channel.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12464184}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12464184 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12464184}}
==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Right hand configuration]]
[[Category: Right hand configuration]]
[[Category: Rna polymerase]]
[[Category: Rna polymerase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 30 13:54:55 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:06:18 2008''

Revision as of 12:06, 28 July 2008

Image:1n38.png

Template:STRUCTURE 1n38

reovirus polymerase lambda3 elongation complex with one phosphodiester bond formed

Template:ABSTRACT PUBMED 12464184

About this Structure

1N38 is a Single protein structure of sequence from Mammalian orthoreovirus 3. Full crystallographic information is available from OCA.

Reference

RNA synthesis in a cage--structural studies of reovirus polymerase lambda3., Tao Y, Farsetta DL, Nibert ML, Harrison SC, Cell. 2002 Nov 27;111(5):733-45. PMID:12464184

Page seeded by OCA on Mon Jul 28 15:06:18 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1n38"
Personal tools