5ztc

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Current revision (10:29, 27 March 2024) (edit) (undo)
 
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<StructureSection load='5ztc' size='340' side='right'caption='[[5ztc]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='5ztc' size='340' side='right'caption='[[5ztc]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ztc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lismo Lismo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZTC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZTC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ztc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Listeria_monocytogenes_EGD-e Listeria monocytogenes EGD-e]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZTC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZTC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lmo2088 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=169963 LISMO])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ztc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ztc OCA], [http://pdbe.org/5ztc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ztc RCSB], [http://www.ebi.ac.uk/pdbsum/5ztc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ztc ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ztc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ztc OCA], [https://pdbe.org/5ztc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ztc RCSB], [https://www.ebi.ac.uk/pdbsum/5ztc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ztc ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q8Y5H4_LISMO Q8Y5H4_LISMO]
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Listeria monocytogenes is a gram-positive food borne pathogen. The lmo2088 belongs to the TetR family of transcriptional regulators from L. monocytogenes. These transcriptional factors regulate multidrug resistance transporters in L. monocytogenes. Here, we report native protein crystal structure of lmo2088 at a resolution of 1.7A. Lmo2088 comprises of an N-terminal DNA binding domain and a variable C-terminal effector binding domain. Furthermore, we identified specific consensus sequences selected by systematic evolution of ligands by exponential enrichment in vitro. The specific binding of lmo2088 with DNA consensus sequence was validated by electrophoretic mobility shift assay, fluorescence polarization and isothermal titration calorimetry. We speculate that the structure of lmo2088 might provide an insight into the regulatory function of lmo2088 of L. monocytogenes.
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X-ray crystal structure of putative transcription regulator lmo2088 from Listeria monocytogenes.,Samad A, Li Y, Zhang C, Chen F, Zeng W, Fan X, Jin T Biochem Biophys Res Commun. 2019 Dec 3;520(2):434-440. doi:, 10.1016/j.bbrc.2019.10.033. Epub 2019 Oct 10. PMID:31607473<ref>PMID:31607473</ref>
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==See Also==
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*[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5ztc" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lismo]]
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[[Category: Listeria monocytogenes EGD-e]]
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[[Category: Jin, T]]
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[[Category: Jin T]]
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[[Category: Samad, A]]
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[[Category: Samad A]]
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[[Category: Tetr family]]
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[[Category: Transcription]]
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Current revision

Apo structure of TetR family transcription regulator Lmo2088 of Listeria monocytogenes EGDe

PDB ID 5ztc

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