2cyh

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2cyh.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2cyh.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2cyh| PDB=2cyh | SCENE= }}
{{STRUCTURE_2cyh| PDB=2cyh | SCENE= }}
-
'''CYCLOPHILIN A COMPLEXED WITH DIPEPTIDE ALA-PRO'''
+
===CYCLOPHILIN A COMPLEXED WITH DIPEPTIDE ALA-PRO===
-
==Overview==
+
<!--
-
The structures of cyclophilin A complexed with dipeptides of Ser-Pro, His-Pro, and Gly-Pro have been determined and refined at high resolution. Comparison of these structures revealed that the dipeptide complexes have the same molecular conformation and the same binding of the dipeptides. The side chains of the N-terminal amino acid of the above dipeptides do not strongly interact with cyclophilin, implying their minor contribution to the cis-trans isomerization and thus accounting for the broad catalytic specificity of the enzyme. The binding of the dipeptides is similar to that of the common substrate succinyl-Ala-Ala-Pro-Phe-p-nitroanilide in terms of the N-terminal hydrogen bonding and the hydrophobic interaction of the proline side chain. However, substantial difference between these structures are observed in (1) hydrogen bonding between the carboxyl terminus of the peptides and Arg55 and between Arg55 and Gln63, (2) the side chain conformation of Arg55, and (3) water binding at the active site. These differences imply either that dipeptides are not substrates but competitive inhibitors of peptidyl-prolyl cis-trans isomerases or that dipeptides are subject to different catalytic mechanisms from tetrapeptides.
+
The line below this paragraph, {{ABSTRACT_PUBMED_8652512}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 8652512 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_8652512}}
==About this Structure==
==About this Structure==
Line 26: Line 30:
[[Category: Binding protein for cyclosporin some]]
[[Category: Binding protein for cyclosporin some]]
[[Category: Cyclophilin]]
[[Category: Cyclophilin]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 30 13:57:03 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:36:17 2008''

Revision as of 06:36, 28 July 2008

Image:2cyh.png

Template:STRUCTURE 2cyh

CYCLOPHILIN A COMPLEXED WITH DIPEPTIDE ALA-PRO

Template:ABSTRACT PUBMED 8652512

About this Structure

2CYH is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1cyh. Full crystallographic information is available from OCA.

Reference

Mechanistic implication of crystal structures of the cyclophilin-dipeptide complexes., Zhao Y, Ke H, Biochemistry. 1996 Jun 11;35(23):7362-8. PMID:8652512

Page seeded by OCA on Mon Jul 28 09:36:17 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2cyh"
Personal tools