NADPH dehydrogenase
From Proteopedia
(Difference between revisions)
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== Function == | == Function == | ||
| - | '''NADPH dehydrogenase''' or '''old yellow enzyme''' (OYE) catalyzes the conversion of NADPH, H+ and acceptor to NADP+ and reduced acceptor<ref>PMID:12803488</ref>. See [[NAD(P)H]]. The acceptor is a quinone. OYE is a flavoenzyme with two cofactors: FAD and FMN. '''NADPH dehydrogenase quinone 1''' (NQO1) reduces quinones to hydroquinones. | + | '''NADPH dehydrogenase''' or '''old yellow enzyme''' or '''NADH:flavin oxidoreductase/NADH oxidase''' or '''prostaglandin F2A synthase''' or '''chromate reductase''' (OYE) catalyzes the conversion of NADPH, H+ and acceptor to NADP+ and reduced acceptor<ref>PMID:12803488</ref>. See [[NAD(P)H]]. The acceptor is a quinone. OYE is a flavoenzyme with two cofactors: FAD and FMN. '''NADPH dehydrogenase quinone 1''' (NQO1) reduces quinones to hydroquinones. |
== Structural highlights == | == Structural highlights == | ||
<scene name='59/595221/Cv/5'>OYE cofactor FMN interacts with the ligand in active site</scene><ref>PMID:11668181</ref>. Water molecules are shown as red spheres. | <scene name='59/595221/Cv/5'>OYE cofactor FMN interacts with the ligand in active site</scene><ref>PMID:11668181</ref>. Water molecules are shown as red spheres. | ||
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**[[1oyb]] – yOYE + FMN + p-hydroxybenzaldehyde <br /> | **[[1oyb]] – yOYE + FMN + p-hydroxybenzaldehyde <br /> | ||
**[[3tjl]] – SsOYE + FMN + malonate - ''Scheffersomyces stipitis'' <br /> | **[[3tjl]] – SsOYE + FMN + malonate - ''Scheffersomyces stipitis'' <br /> | ||
| + | **[[6s32]] – OYE + FMN + benzamidine – ''Chroococcidiopsis thermalis''<br /> | ||
| + | **[[6s31]] – GsOYE + FMN + benzaldehyde – ''Galdieria sulphuraria''<br /> | ||
| + | **[[6s0g]], [[6s23]] – GsOYE + FMN <br /> | ||
| + | **[[6agz]] – OYE + FMN - ''Pichia''<br /> | ||
| + | **[[3kru]], [[3krz]] – OYE + FMN – ''Thermoanaerobacter pseudethanolicus''<br /> | ||
| + | **[[3atz]] – TcOYE + FMN + benzaldehyde – ''Trypanosoma cruzi''<br /> | ||
| + | **[[3aty]] – TcOYE + FMN <br /> | ||
| + | **[[2gou]], [[2gqa]] – SoOYE + FMN – ''Shewanella oneidensis''<br /> | ||
| + | **[[2gq9]] – SoOYE + FMN + benzaldehyde <br /> | ||
| + | **[[7o0t]] – OYE + FMN – ''Chloroflexus aggregans''<br /> | ||
| + | **[[3hgj]] – TsOYE + FMN + benzaldehyde – ''Thermus scotoductus''<br /> | ||
| + | **[[3hf3]] – TsOYE + FMN <br /> | ||
*NADPH dehydrogenase 1 | *NADPH dehydrogenase 1 | ||
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**[[5v4p]] – yOYE 3 + FMN + p-hydroxybenzaldehyde <br /> | **[[5v4p]] – yOYE 3 + FMN + p-hydroxybenzaldehyde <br /> | ||
**[[5v4v]] – yOYE 3 + FMN + nicotinamide <br /> | **[[5v4v]] – yOYE 3 + FMN + nicotinamide <br /> | ||
| + | |||
| + | *NADPH dehydrogenase 4 | ||
| + | |||
| + | **[[4b5n]] – SoOYE 4 + FMN <br /> | ||
*NADPH dehydrogenase quinone 1 | *NADPH dehydrogenase quinone 1 | ||
Revision as of 11:25, 16 November 2021
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3D Structures of NADPH dehydrogenase
Updated on 16-November-2021
References
- ↑ Ryu JY, Suh KH, Chung YH, Park YM, Chow WS, Park YI. NADPH dehydrogenase-mediated respiratory electron transport in thylakoid membranes of the cyanobacterium Synechocystis sp. PCC 6803 is inactive in the light. Mol Cells. 2003 Apr 30;15(2):240-4. PMID:12803488
- ↑ Brown BJ, Hyun JW, Duvvuri S, Karplus PA, Massey V. The role of glutamine 114 in old yellow enzyme. J Biol Chem. 2002 Jan 18;277(3):2138-45. Epub 2001 Oct 19. PMID:11668181 doi:10.1074/jbc.M108453200
