2pjr

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[[Image:2pjr.gif|left|200px]]
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{{STRUCTURE_2pjr| PDB=2pjr | SCENE= }}
{{STRUCTURE_2pjr| PDB=2pjr | SCENE= }}
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'''HELICASE PRODUCT COMPLEX'''
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===HELICASE PRODUCT COMPLEX===
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==Overview==
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We have determined two different structures of PcrA DNA helicase complexed with the same single strand tailed DNA duplex, providing snapshots of different steps on the catalytic pathway. One of the structures is of a complex with a nonhydrolyzable analog of ATP and is thus a "substrate" complex. The other structure contains a bound sulphate ion that sits in a position equivalent to that occupied by the phosphate ion produced after ATP hydrolysis, thereby mimicking a "product" complex. In both complexes, the protein is monomeric. Large and distinct conformational changes occur on binding DNA and the nucleotide cofactor. Taken together, these structures provide evidence against an "active rolling" model for helicase action but are instead consistent with an "inchworm" mechanism.
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{{ABSTRACT_PUBMED_10199404}}
==About this Structure==
==About this Structure==
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[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Product complex]]
[[Category: Product complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:46:57 2008''

Revision as of 12:47, 28 July 2008

Image:2pjr.png

Template:STRUCTURE 2pjr

HELICASE PRODUCT COMPLEX

Template:ABSTRACT PUBMED 10199404

About this Structure

2PJR is a Protein complex structure of sequences from Geobacillus stearothermophilus. Full crystallographic information is available from OCA.

Reference

Crystal structures of complexes of PcrA DNA helicase with a DNA substrate indicate an inchworm mechanism., Velankar SS, Soultanas P, Dillingham MS, Subramanya HS, Wigley DB, Cell. 1999 Apr 2;97(1):75-84. PMID:10199404

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