1uzx
From Proteopedia
(New page: 200px<br /> <applet load="1uzx" size="450" color="white" frame="true" align="right" spinBox="true" caption="1uzx, resolution 1.85Å" /> '''A COMPLEX OF THE VP...) |
|||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1UZX is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]] with SO4 and MES as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UZX OCA]]. | + | 1UZX is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]] and [[http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]] with SO4 and MES as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UZX OCA]]. |
==Reference== | ==Reference== | ||
Structural insights into endosomal sorting complex required for transport (ESCRT-I) recognition of ubiquitinated proteins., Teo H, Veprintsev DB, Williams RL, J Biol Chem. 2004 Jul 2;279(27):28689-96. Epub 2004 Mar 24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15044434 15044434] | Structural insights into endosomal sorting complex required for transport (ESCRT-I) recognition of ubiquitinated proteins., Teo H, Veprintsev DB, Williams RL, J Biol Chem. 2004 Jul 2;279(27):28689-96. Epub 2004 Mar 24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15044434 15044434] | ||
| + | [[Category: Bos taurus]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
| Line 28: | Line 29: | ||
[[Category: vps23]] | [[Category: vps23]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:21:04 2007'' |
Revision as of 09:16, 30 October 2007
|
A COMPLEX OF THE VPS23 UEV WITH UBIQUITIN
Overview
The endosomal sorting complex required for transport (ESCRT-I) is a, 350-kDa complex of three proteins, Vps23, Vps28, and Vps37. The N-terminal, ubiquitin-conjugating enzyme E2 variant (UEV) domain of Vps23 is required, for sorting ubiquitinated proteins into the internal vesicles of, multivesicular bodies. UEVs are homologous to E2 ubiquitin ligases but, lack the conserved cysteine residue required for catalytic activity. The, crystal structure of the yeast Vps23 UEV in a complex with ubiquitin (Ub), shows the detailed interactions made with the bound Ub. Compared with the, solution structure of the Tsg101 UEV (the human homologue of Vps23) in the, absence of Ub, two loops that are conserved among the ESCRT-I UEVs move, toward each other to grip the Ub in a pincer-like grasp. The ... [(full description)]
About this Structure
1UZX is a [Protein complex] structure of sequences from [Bos taurus] and [Saccharomyces cerevisiae] with SO4 and MES as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structural insights into endosomal sorting complex required for transport (ESCRT-I) recognition of ubiquitinated proteins., Teo H, Veprintsev DB, Williams RL, J Biol Chem. 2004 Jul 2;279(27):28689-96. Epub 2004 Mar 24. PMID:15044434
Page seeded by OCA on Tue Oct 30 11:21:04 2007
