This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


114d

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:114d.gif|left|200px]]
+
{{Seed}}
 +
[[Image:114d.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_114d| PDB=114d | SCENE= }}
{{STRUCTURE_114d| PDB=114d | SCENE= }}
-
'''INOSINE-ADENINE BASE PAIRS IN A B-DNA DUPLEX'''
+
===INOSINE-ADENINE BASE PAIRS IN A B-DNA DUPLEX===
-
==Overview==
+
<!--
-
The structure of the synthetic deoxydodecamer d(C-G-C-I-A-A-T-T-A-G-C-G) has been determined by single crystal X-ray diffraction techniques at 2.5A resolution. The refinement converged with a crystallographic residual, R = 0.19 and the location of 64 solvent molecules. The sequence crystallises as a B-DNA helix with 10 Watson-Crick base-pairs (4 A.T. and 6 G.C) and 2 inosine.adenine (I.A) pairs. The present work shows that in the purine.purine base-pairs the adenine adopts syn orientation with respect to the furanose moiety while the inosine is in the trans (anti) orientation. Two hydrogen bonds link the I.A. base-pair, one between N-1(I) and N-7(A), the other between O-6(I) and N-6(A). This bulky purine.purine base-pair is incorporated in the double helix at two positions with little distortion of either local or global conformation. The pairing observed in this study is presented as a model for I.A base-pairs in RNA codon-anticodon interactions and may help explain the thermodynamic stability of inosine containing base-pairs. Conformational parameters and base stacking interactions are presented and where appropriate compared with those of the native compound, d(C-G-C-G-A-A-T-T-C-G-C-G) and with other studies of oligonucleotides containing purine.purine base-pairs.
+
The line below this paragraph, {{ABSTRACT_PUBMED_3671069}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 3671069 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_3671069}}
==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Mismatched]]
[[Category: Mismatched]]
[[Category: Modified]]
[[Category: Modified]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:26:27 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:23:18 2008''

Revision as of 12:23, 30 June 2008

Image:114d.png

Template:STRUCTURE 114d

INOSINE-ADENINE BASE PAIRS IN A B-DNA DUPLEX

Template:ABSTRACT PUBMED 3671069

About this Structure

Full crystallographic information is available from OCA.

Reference

Inosine.adenine base pairs in a B-DNA duplex., Corfield PW, Hunter WN, Brown T, Robinson P, Kennard O, Nucleic Acids Res. 1987 Oct 12;15(19):7935-49. PMID:3671069

Page seeded by OCA on Mon Jun 30 15:23:18 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/114d"
Personal tools