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114d

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{{STRUCTURE_114d| PDB=114d | SCENE= }}
{{STRUCTURE_114d| PDB=114d | SCENE= }}
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'''INOSINE-ADENINE BASE PAIRS IN A B-DNA DUPLEX'''
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===INOSINE-ADENINE BASE PAIRS IN A B-DNA DUPLEX===
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==Overview==
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The structure of the synthetic deoxydodecamer d(C-G-C-I-A-A-T-T-A-G-C-G) has been determined by single crystal X-ray diffraction techniques at 2.5A resolution. The refinement converged with a crystallographic residual, R = 0.19 and the location of 64 solvent molecules. The sequence crystallises as a B-DNA helix with 10 Watson-Crick base-pairs (4 A.T. and 6 G.C) and 2 inosine.adenine (I.A) pairs. The present work shows that in the purine.purine base-pairs the adenine adopts syn orientation with respect to the furanose moiety while the inosine is in the trans (anti) orientation. Two hydrogen bonds link the I.A. base-pair, one between N-1(I) and N-7(A), the other between O-6(I) and N-6(A). This bulky purine.purine base-pair is incorporated in the double helix at two positions with little distortion of either local or global conformation. The pairing observed in this study is presented as a model for I.A base-pairs in RNA codon-anticodon interactions and may help explain the thermodynamic stability of inosine containing base-pairs. Conformational parameters and base stacking interactions are presented and where appropriate compared with those of the native compound, d(C-G-C-G-A-A-T-T-C-G-C-G) and with other studies of oligonucleotides containing purine.purine base-pairs.
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(as it appears on PubMed at http://www.pubmed.gov), where 3671069 is the PubMed ID number.
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{{ABSTRACT_PUBMED_3671069}}
==About this Structure==
==About this Structure==
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:23:18 2008''

Revision as of 12:23, 30 June 2008

Image:114d.png

Template:STRUCTURE 114d

INOSINE-ADENINE BASE PAIRS IN A B-DNA DUPLEX

Template:ABSTRACT PUBMED 3671069

About this Structure

Full crystallographic information is available from OCA.

Reference

Inosine.adenine base pairs in a B-DNA duplex., Corfield PW, Hunter WN, Brown T, Robinson P, Kennard O, Nucleic Acids Res. 1987 Oct 12;15(19):7935-49. PMID:3671069

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