115d

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{{STRUCTURE_115d| PDB=115d | SCENE= }}
{{STRUCTURE_115d| PDB=115d | SCENE= }}
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'''ORDERED WATER STRUCTURE IN AN A-DNA OCTAMER AT 1.7 ANGSTROMS RESOLUTION'''
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===ORDERED WATER STRUCTURE IN AN A-DNA OCTAMER AT 1.7 ANGSTROMS RESOLUTION===
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==Overview==
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The crystal structure of the deoxyoctamer d(G-G-Br U-A-BrU-A-C-C) was refined to a resolution of 1.7 A using combined diffractometer and synchrotron data. The analysis was carried out independently in two laboratories using different procedures. Although the final results are identical the comparison of the two approaches highlights potential problems in the refinement of oligonucleotides when only limited data are available. As part of the analysis the positions of 84 solvent molecules in the asymmetric unit were established. The DNA molecule is highly solvated, particularly the phosphate-sugar back-bone and the functional groups of the bases. The major groove contains, in the central BrU-A-BrU-A region, a ribbon of water molecules forming closed pentagons with shared edges. These water molecules are linked to the base O and N atoms and to the solvent chains connecting the O-1 phosphate oxygen atoms on each strand. The minor groove is also extensively hydrated with a continuous network in the central region and other networks at each end. The pattern of hydration is briefly compared with that observed in the structure of a B-dodecamer.
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(as it appears on PubMed at http://www.pubmed.gov), where 3271041 is the PubMed ID number.
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{{ABSTRACT_PUBMED_3271041}}
==About this Structure==
==About this Structure==
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[[Category: Double helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:26:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:23:29 2008''

Revision as of 12:23, 30 June 2008

Image:115d.png

Template:STRUCTURE 115d

ORDERED WATER STRUCTURE IN AN A-DNA OCTAMER AT 1.7 ANGSTROMS RESOLUTION

Template:ABSTRACT PUBMED 3271041

About this Structure

Full crystallographic information is available from OCA.

Reference

Ordered water structure in an A-DNA octamer at 1.7 A resolution., Kennard O, Cruse WB, Nachman J, Prange T, Shakked Z, Rabinovich D, J Biomol Struct Dyn. 1986 Feb;3(4):623-47. PMID:3271041

Page seeded by OCA on Mon Jun 30 15:23:29 2008

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