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1lqq
From Proteopedia
(Difference between revisions)
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<StructureSection load='1lqq' size='340' side='right'caption='[[1lqq]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''> | <StructureSection load='1lqq' size='340' side='right'caption='[[1lqq]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1lqq]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1lqq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leiurus_quinquestriatus_quinquestriatus Leiurus quinquestriatus quinquestriatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LQQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LQQ FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lqq OCA], [https://pdbe.org/1lqq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lqq RCSB], [https://www.ebi.ac.uk/pdbsum/1lqq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lqq ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/SCX3_LEIQU SCX3_LEIQU]] Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This contractive toxin is highly toxic both to mammals and insects. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 06:48, 18 August 2021
ANTI-MAMMAL AND ANTI-INSECT LQQIII SCORPION TOXIN, NMR, 15 STRUCTURES
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