Phospholipase A2

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Removing the labels, atropine can be seen making contact with the atoms emphasized by the space filling model, interacting with the <scene name='Sandbox_53/Phospholipase2a_interactions/1'>active site</scene> of phospholipase 2A through white as-tricks.
Removing the labels, atropine can be seen making contact with the atoms emphasized by the space filling model, interacting with the <scene name='Sandbox_53/Phospholipase2a_interactions/1'>active site</scene> of phospholipase 2A through white as-tricks.
 +
 +
== 3D Structures of Phospholipase A2 ==
 +
[[Phospholipase A2 3D structures]]
 +
</StructureSection>
</StructureSection>
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*Phospholipase A2
*Phospholipase A2
 +
**[[1ayp]], [[1bbc]], [[1pod]] – hPLA2 – human<br />
 +
**[[1rlw]] – hPLA2 CALB domain<br />
**[[1une]], [[1mkt]], [[1irb]], [[1bp2]], [[1bpq]], [[1g4i]], [[2bp2]], [[2bpp]] - bPLA2 – bovine<br />
**[[1une]], [[1mkt]], [[1irb]], [[1bp2]], [[1bpq]], [[1g4i]], [[2bp2]], [[2bpp]] - bPLA2 – bovine<br />
-
**[[2zp3]], [[2zp4]], [[2zp5]], [[1c74]], [[1kvw]], [[1kvx]], [[1kvy]], [[1ceh]], [[1mks]], [[1mku]], [[1vkq]], [[1vl9]], [[2bax]], [[2bch]], [[2bd1]], [[1o3w]], [[1gh4]] – bPLA2 (mutant) – bovine<br />
+
**[[2zp3]], [[2zp4]], [[2zp5]], [[1c74]], [[1kvw]], [[1kvx]], [[1kvy]], [[1ceh]], [[1mks]], [[1mku]], [[1vkq]], [[1vl9]], [[2bax]], [[2bch]], [[2bd1]], [[1o3w]], [[1gh4]] – bPLA2 (mutant) <br />
**[[1bvm]] – bPLA2 - NMR<br />
**[[1bvm]] – bPLA2 - NMR<br />
 +
**[[1p2p]], [[4p2p]] – pPLA2 - pig<br />
 +
**[[1y6p]], [[2phi]], [[3p2p]] – pPLA2 (mutant) – pig<br />
 +
**[[1sfv]], [[1sfw]], [[1pir]], [[1pis]] – pPLA2 - NMR<br />
**[[1qll]], [[2q2j]] – PLA2 – ''Bothrops pirajai''<br />
**[[1qll]], [[2q2j]] – PLA2 – ''Bothrops pirajai''<br />
**[[2qog]] – PLA2 – ''Crotalus durissus''<br />
**[[2qog]] – PLA2 – ''Crotalus durissus''<br />
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**[[2osn]], [[1fe5]], [[1dpy]] – kPLA2 – krait<br />
**[[2osn]], [[1fe5]], [[1dpy]] – kPLA2 – krait<br />
**[[1g0z]], [[1g2x]] – kPLA2 (mutant)<br />
**[[1g0z]], [[1g2x]] – kPLA2 (mutant)<br />
-
**[[2wg7]], [[2wg8]] – rPLA2 – rice<br />
 
-
**[[1p2p]], [[4p2p]] – pPLA2 - pig<br />
 
-
**[[1y6p]], [[2phi]], [[3p2p]] – pPLA2 (mutant) – pig<br />
 
-
**[[1sfv]], [[1sfw]], [[1pir]], [[1pis]] – pPLA2 - NMR<br />
 
**[[1yxh]] – NsPLA2 – ''Naja sagittifera''<br />
**[[1yxh]] – NsPLA2 – ''Naja sagittifera''<br />
**[[1oz6]], [[2qhe]] – PLA2 – ''Echis carinatus''<br />
**[[1oz6]], [[2qhe]] – PLA2 – ''Echis carinatus''<br />
-
**[[1it4]], [[1it5]] – PLA2 – Stretomyces violaceoruber – NMR<br />
 
**[[1mg6]] – PLA2 – ''Agkistrodon acutus''<br />
**[[1mg6]] – PLA2 – ''Agkistrodon acutus''<br />
**[[1s8g]], [[1s8h]], [[1s8i]] – PLA2 – copperhead<br />
**[[1s8g]], [[1s8h]], [[1s8i]] – PLA2 – copperhead<br />
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**[[1aok]], [[1jlt]], [[1q5t]], [[1rgb]], [[3dih]], [[3g8g]], [[3g8h]] – PLA2 – ''Vipera ammodytes''<br />
**[[1aok]], [[1jlt]], [[1q5t]], [[1rgb]], [[3dih]], [[3g8g]], [[3g8h]] – PLA2 – ''Vipera ammodytes''<br />
**[[2i0u]] – PLA2 – ''Vipera nikolskii''<br />
**[[2i0u]] – PLA2 – ''Vipera nikolskii''<br />
-
**[[1ayp]], [[1bbc]], [[1pod]] – hPLA2 – human<br />
 
-
**[[1rlw]] – hPLA2 CALB domain<br />
 
-
**[[1faz]], [[1kp4]] – PLA2 – ''Streptomyces violaceruber''<br />
 
**[[1god]] – PLA2 – ''Cerrophidion godmani''<br />
**[[1god]] – PLA2 – ''Cerrophidion godmani''<br />
**[[1gp7]], [[1m8t]] – PLA2 – ''Ophiophagus hanna''<br />
**[[1gp7]], [[1m8t]] – PLA2 – ''Ophiophagus hanna''<br />
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**[[2aoz]] – PLA2 – ''Atropoides nummifer''<br />
**[[2aoz]] – PLA2 – ''Atropoides nummifer''<br />
**[[3v9m]] – PLA2 – king brown snake<br />
**[[3v9m]] – PLA2 – king brown snake<br />
 +
**[[2wg7]], [[2wg8]] – rPLA2 – rice<br />
 +
**[[1faz]], [[1kp4]] – SvPLA2 – ''Streptomyces violaceruber''<br />
 +
**[[1it4]], [[1it5]] – SvPLA2 – NMR<br />
*Phospholipase A2 group I
*Phospholipase A2 group I
**[[3elo]] – hPLA2G1B<br />
**[[3elo]] – hPLA2G1B<br />
-
**[[3q4y]] - PLA2G1 - Andaman cobra <br />
 
**[[3fvi]], [[3fvj]] – pPLA2G1B+octyl sulfate<br />
**[[3fvi]], [[3fvj]] – pPLA2G1B+octyl sulfate<br />
**[[3qlm]] - pPLA2G1B + hexadecanoic acid<br />
**[[3qlm]] - pPLA2G1B + hexadecanoic acid<br />
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**[[4g5i]] – pPLA2 + DBP<br />
**[[4g5i]] – pPLA2 + DBP<br />
**[[4o1y]] – pPLA2 + naphthalene acetic acid<br />
**[[4o1y]] – pPLA2 + naphthalene acetic acid<br />
 +
**[[3q4y]] - PLA2G1 - Andaman cobra <br />
**[[3osh]] – NnPLA2G1+atropine
**[[3osh]] – NnPLA2G1+atropine
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**[[1j1a]], [[3u8b]] – hPLA2G2A<br />
**[[1j1a]], [[3u8b]] – hPLA2G2A<br />
**[[1n28]], [[1n29]] – hPLA2G2A (mutant)<br />
**[[1n28]], [[1n29]] – hPLA2G2A (mutant)<br />
-
**[[1cl5]], [[1fb2]], [[1vip]], [[2pvt]], [[2pyc]], [[5vet]] – DrPLA2 – ''Daboia russellii''<br />
 
-
**[[2qhw]] – DrPLA2 + gramine derivative<br />
 
-
**[[2que]] – DrPLA2 + ajamaline + anisic acid<br />
 
**[[1kqu]], [[1kvo]] – hPLA2G2A+substrate analog<br />
**[[1kqu]], [[1kvo]] – hPLA2G2A+substrate analog<br />
**[[3u8d]], [[3u8h]], [[3u8i]], [[4hmb]] - hPLA2G2A + inhibitor<br />
**[[3u8d]], [[3u8h]], [[3u8i]], [[4hmb]] - hPLA2G2A + inhibitor<br />
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**[[5wzw]], [[5wzv]], [[5wzu]], [[5wzt]], [[5wzs]], [[5wzo]], [[5wzm]] - hPLA2G2E + inhibitor<br />
**[[5wzw]], [[5wzv]], [[5wzu]], [[5wzt]], [[5wzs]], [[5wzo]], [[5wzm]] - hPLA2G2E + inhibitor<br />
**[[5yse]] - hPLA2G2E (mutant) + inhibitor<br />
**[[5yse]] - hPLA2G2E (mutant) + inhibitor<br />
-
**[[3g8f]] – DrPLA2G2+polypeptide<br />
 
**[[3mlm]] – PLA2G2 + myristic acid – ''Neuwiedi lancehead''<br />
**[[3mlm]] – PLA2G2 + myristic acid – ''Neuwiedi lancehead''<br />
-
**[[4fga]], [[4gfy]], [[4gld]] – DrPLA2 + polypeptide
+
**[[1cl5]], [[1fb2]], [[1vip]], [[2pvt]], [[2pyc]], [[5vet]] – DrPLA2 – ''Daboia russellii''<br />
 +
**[[2qhw]] – DrPLA2 + gramine derivative<br />
 +
**[[2que]] – DrPLA2 + ajamaline + anisic acid<br />
 +
**[[4fga]], [[4gfy]], [[4gld]] – DrPLA2 + polypeptide<br />
 +
**[[3g8f]] – DrPLA2G2+polypeptide<br />
*Human PLA2 group IVd
*Human PLA2 group IVd
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*Phospholipase A2 +inhibitor
*Phospholipase A2 +inhibitor
-
**[[3o4m]], [[3hsw]] – PLA2+inhibitor <br />
+
**[[1db4]], [[1db5]], [[1dcy]] – hPLA2+indole<br />
 +
**[[1poe]] – hPLA2+phosphonyl inhibitor<br />
 +
**[[1fdk]] – bPLA2+MJ33<br />
 +
**[[1mkv]] – bPLA2+transition state analog<br />
 +
**[[1o2e]] – bPLA2 (mutant)+anisic acid<br />
 +
**[[2b96]] - bPLA2+benzoic acid derivative<br />
 +
**[[3bp2]] – bPLA2+pyruvic acid<br />
 +
**[[3o4m]], [[3hsw]] – pPLA2+inhibitor <br />
**[[2azy]], [[2azz]], [[2b00]], [[2b01]], [[2b03]], [[2b04]] – pPLA2+cholate derivative<br />
**[[2azy]], [[2azz]], [[2b00]], [[2b01]], [[2b03]], [[2b04]] – pPLA2+cholate derivative<br />
**[[1y6o]], [[1fx9]], [[1fxf]] – pPLA2+MJ33<br />
**[[1y6o]], [[1fx9]], [[1fxf]] – pPLA2+MJ33<br />
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**[[1oxr]] – NsPLA2+aspirin<br />
**[[1oxr]] – NsPLA2+aspirin<br />
**[[1bk9]] – AhPLA2+PBPB<br />
**[[1bk9]] – AhPLA2+PBPB<br />
-
**[[1fdk]] – bPLA2+MJ33<br />
 
-
**[[1mkv]] – bPLA2+transition state analog<br />
 
-
**[[1o2e]] – bPLA2 (mutant)+anisic acid<br />
 
-
**[[2b96]] - bPLA2+benzoic acid derivative<br />
 
-
**[[3bp2]] – bPLA2+pyruvic acid<br />
 
**[[1pob]] - NnPLA2+transition state analog<br />
**[[1pob]] - NnPLA2+transition state analog<br />
**[[1poc]] - PLA2+transition state analog – Honey bee<br />
**[[1poc]] - PLA2+transition state analog – Honey bee<br />
-
**[[1db4]], [[1db5]], [[1dcy]] – hPLA2+indole<br />
 
-
**[[1poe]] – hPLA2+phosphonyl inhibitor<br />
 
**[[1fv0]] – DrPLA2+aristolochic acid<br />
**[[1fv0]] – DrPLA2+aristolochic acid<br />
**[[1sv3]] - DrPLA2+benzoic acid derivative<br />
**[[1sv3]] - DrPLA2+benzoic acid derivative<br />
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*Lp-PLA2
*Lp-PLA2
 +
**[[3d59]] – hLP-PLA2 residues 47-429 <br />
**[[1wab]] – bLP-PLA2 + acetate <br />
**[[1wab]] – bLP-PLA2 + acetate <br />
**[[1bwp]], 1bwq]], 1bwr]], 1es9]] – bLP-PLA2 ( mutant) <br />
**[[1bwp]], 1bwq]], 1bwr]], 1es9]] – bLP-PLA2 ( mutant) <br />
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**[[1uuj]] - mLP-PLA2 α subunit N terminal – mouse<br />
**[[1uuj]] - mLP-PLA2 α subunit N terminal – mouse<br />
**[[1vyh]] - mLP-PLA2 α subunit C terminal + β subunit<br />
**[[1vyh]] - mLP-PLA2 α subunit C terminal + β subunit<br />
-
**[[3d59]] – hLP-PLA2 residues 47-429 <br />
 
*Lp-PLA2 binary complexes
*Lp-PLA2 binary complexes
-
**[[3dt6]] - bLP-PLA2 α subunit (mutant) + paraoxon<br />
 
-
**[[3dt8]] - bLP-PLA2 α subunit (mutant) + sarin<br />
 
**[[3dt9]] - bLP-PLA2 α subunit (mutant) + soman<br />
**[[3dt9]] - bLP-PLA2 α subunit (mutant) + soman<br />
**[[3d5e]] - hLP-PLA2 residues 47-429 + paraoxon<br />
**[[3d5e]] - hLP-PLA2 residues 47-429 + paraoxon<br />
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**[[5i8p]], [[5i9i]], [[5jad]], [[5jah]], [[5jal]], [[5jan]], [[5jao]], [[5jap]], [[5jar]], [[5jas]], [[5jat]], [[5jau]], [[5lp1]], [[5lz2]], [[5lz8]], [[5lz9]] - hLP-PLA2 residues 47-429 + inhibitor<br />
**[[5i8p]], [[5i9i]], [[5jad]], [[5jah]], [[5jal]], [[5jan]], [[5jao]], [[5jap]], [[5jar]], [[5jas]], [[5jat]], [[5jau]], [[5lp1]], [[5lz2]], [[5lz8]], [[5lz9]] - hLP-PLA2 residues 47-429 + inhibitor<br />
**[[5lyy]], [[5lz4]], [[5lz5]], [[5lz7]] - hLP-PLA2 residues 47-429 (mutant) + inhibitor<br />
**[[5lyy]], [[5lz4]], [[5lz5]], [[5lz7]] - hLP-PLA2 residues 47-429 (mutant) + inhibitor<br />
 +
**[[3dt6]] - bLP-PLA2 α subunit (mutant) + paraoxon<br />
 +
**[[3dt8]] - bLP-PLA2 α subunit (mutant) + sarin<br />
 +
**[[3dt9]] - bLP-PLA2 α subunit (mutant) + soman<br />
*Bothrops toxins
*Bothrops toxins
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*Pro-Phospholipase A2
*Pro-Phospholipase A2
 +
**[[4bp2]] – bPPLA2<br />
**[[1hn4]] – pPPLA2+MJ33<br />
**[[1hn4]] – pPPLA2+MJ33<br />
-
**[[4bp2]] – bPPLA2
+
 
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:57, 18 November 2019

Phospholipase A2 complex with ethanol, phosphate and Ca+2 ion (green) (PDB code 1yxh)

Drag the structure with the mouse to rotate

3D Structures of Phospholipase A2

Updated on 18-November-2019

References

  1. ↑ Dennis EA. Diversity of group types, regulation, and function of phospholipase A2. J Biol Chem. 1994 May 6;269(18):13057-60. PMID:8175726
  2. ↑ Leitinger N, Watson AD, Hama SY, Ivandic B, Qiao JH, Huber J, Faull KF, Grass DS, Navab M, Fogelman AM, de Beer FC, Lusis AJ, Berliner JA. Role of group II secretory phospholipase A2 in atherosclerosis: 2. Potential involvement of biologically active oxidized phospholipids. Arterioscler Thromb Vasc Biol. 1999 May;19(5):1291-8. PMID:10323782
  3. ↑ Lapointe S, Brkovic A, Cloutier I, Tanguay JF, Arm JP, Sirois MG. Group V secreted phospholipase A2 contributes to LPS-induced leukocyte recruitment. J Cell Physiol. 2010 Jul;224(1):127-34. doi: 10.1002/jcp.22106. PMID:20232296 doi:http://dx.doi.org/10.1002/jcp.22106
  4. ↑ Hallstrand TS, Lai Y, Hooper KA, Oslund RC, Altemeier WA, Matute-Bello G, Gelb MH. Endogenous secreted phospholipase A2 group X regulates cysteinyl leukotrienes synthesis by human eosinophils. J Allergy Clin Immunol. 2016 Jan;137(1):268-77.e8. doi:, 10.1016/j.jaci.2015.05.026. Epub 2015 Jun 30. PMID:26139511 doi:http://dx.doi.org/10.1016/j.jaci.2015.05.026
  5. ↑ Platt RW, Brookhart MA, Cole SR, Westreich D, Schisterman EF. Reply to taguri and matsuyama. Stat Med. 2013 Sep 10;32(20):3592-3. doi: 10.1002/sim.5805. PMID:23943550 doi:http://dx.doi.org/10.1002/sim.5805
  6. ↑ Duncan RE, Sarkadi-Nagy E, Jaworski K, Ahmadian M, Sul HS. Identification and functional characterization of adipose-specific phospholipase A2 (AdPLA). J Biol Chem. 2008 Sep 12;283(37):25428-36. doi: 10.1074/jbc.M804146200. Epub 2008, Jul 9. PMID:18614531 doi:http://dx.doi.org/10.1074/jbc.M804146200
  7. ↑ Tjoelker LW, Wilder C, Eberhardt C, Stafforini DM, Dietsch G, Schimpf B, Hooper S, Le Trong H, Cousens LS, Zimmerman GA, Yamada Y, McIntyre TM, Prescott SM, Gray PW. Anti-inflammatory properties of a platelet-activating factor acetylhydrolase. Nature. 1995 Apr 6;374(6522):549-53. PMID:7700381 doi:http://dx.doi.org/10.1038/374549a0
  8. ↑ Quach ND, Arnold RD, Cummings BS. Secretory phospholipase A2 enzymes as pharmacological targets for treatment of disease. Biochem Pharmacol. 2014 Aug 15;90(4):338-48. doi: 10.1016/j.bcp.2014.05.022. Epub, 2014 Jun 4. PMID:24907600 doi:http://dx.doi.org/10.1016/j.bcp.2014.05.022
  9. ↑ Tellis CC, Tselepis AD. The role of lipoprotein-associated phospholipase A2 in atherosclerosis may depend on its lipoprotein carrier in plasma. Biochim Biophys Acta. 2009 May;1791(5):327-38. doi: 10.1016/j.bbalip.2009.02.015. PMID:19272461 doi:http://dx.doi.org/10.1016/j.bbalip.2009.02.015
  10. ↑ Singh N, Jabeen T, Sharma S, Somvanshi RK, Dey S, Srinivasan A, Singh TP. Specific binding of non-steroidal anti-inflammatory drugs (NSAIDs) to phospholipase A2: structure of the complex formed between phospholipase A2 and diclofenac at 2.7 A resolution. Acta Crystallogr D Biol Crystallogr. 2006 Apr;62(Pt 4):410-6. Epub 2006, Mar 18. PMID:16552142 doi:10.1107/S0907444906003660
  11. ↑ Crystal structure of porcine pancreatic phospholipase a2 in complex with 2-methoxycyclohexa-2-5-diene-1,4-dione. Dileep KV, Tintu I, Mandal PK, Karthe P, Haridas M, Sadasivan C. Frontiers In Life Sci. (2012) doi:http://dx.doi.org/10.1080/21553769.2012.689262
  12. ↑ Kumar, Jainendra; Bala, Priti; Vihwal, Preeti. Analysis of Interaction of atropine with phospholipase A2 (1th6.pdb). Department of Botany and Biotechnlogy, College of Commerce, Patna, India.
  13. ↑ Phospholipase A2. http://www.worldlingo.com/ma/enwiki/en/Phospholipase_A2
  14. ↑ Phospholipase A2. http://www.worldlingo.com/ma/enwiki/en/Phospholipase_A2
  15. ↑ Phospholipase A2. http://www.worldlingo.com/ma/enwiki/en/Phospholipase_A2
  16. ↑ pla2. pla2.gif

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