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Penicillin-binding protein
From Proteopedia
(Difference between revisions)
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</StructureSection> | </StructureSection> | ||
| - | ==3D structures of penicillin-binding protein== | ||
| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *'''Penicillin-binding protein''' | ||
| - | |||
| - | **[[1qme]], [[1rp5]], [[2z2l]], [[5oau]] – SpPBP 2X – ''Streptococcus pneumoniae''<br /> | ||
| - | **[[1k25]], [[1pyy]] – SpPBP 2X (mutant) <br /> | ||
| - | **[[5u47]] - PBP 2X – ''Streptococcus thermophilus''<br /> | ||
| - | **[[2fff]] - SpPBP 1B<br /> | ||
| - | **[[2bg1]], [[2xd5]] - SpPBP 1B (mutant) <br /> | ||
| - | **[[2c6w]], [[2v2f]] - SpPBP 1A <br /> | ||
| - | **[[2wad]], [[2wae]], [[2waf]] – SpPBP 2B<br /> | ||
| - | **[[3vma]] – EcPBP 1B - ''Escherichia coli''<br /> | ||
| - | **[[6g5r]], [[6fzk]] – EcPBP 1B UB2H domain – NMR<br /> | ||
| - | **[[4bjp]] – EcPBP 3 residues 67-577<br /> | ||
| - | **[[4bjq]] – EcPBP 3 residues 88-165<br /> | ||
| - | **[[2ex2]] – EcPBP 4<br /> | ||
| - | **[[1nzo]], [[1nzu]] – EcPBP 5<br /> | ||
| - | **[[1hd8]], [[1nj4]], [[1sdn]] – EcPBP 5 (mutant) <br /> | ||
| - | **[[3it9]] – EcPBP 6<br /> | ||
| - | **[[5tro]] - SaPBP 1 dimerization and transpeptidation domains – ''Staphylococcus aureus''<br /> | ||
| - | **[[1mwr]], [[1vqq]], [[4bl2]], [[4bl3]], [[4cpk]] - SaPBP 2A (mutant) <br /> | ||
| - | **[[2olu]], [[3dwk]], [[5m1a]], [[5m19]], [[5m18]] – SaPBP 2<br /> | ||
| - | **[[3vsk]] - SaPBP 3<br /> | ||
| - | **[[1tvf]] – SaPBP 4<br /> | ||
| - | **[[6dz8]], [[6c3k]] – SaPBP 4 (mutant)<br /> | ||
| - | **[[1w5d]] – BsPBP 4A – ''Bacillus subtilis''<br /> | ||
| - | **[[3mfd]] – BsPBP 5*<br /> | ||
| - | **[[2oqo]] – AaPBP 1A – ''Aquifex aeolicus''<br /> | ||
| - | **[[3equ]] – NgPBP 2 – ''Neisseria gonorrhoeae''<br /> | ||
| - | **[[3eqv]], [[5ksh]] – NgPBP 2 (mutant) <br /> | ||
| - | **[[6p52]], [[6p53]] – NgPBP 2 transpeptidase domain<br /> | ||
| - | **[[6p56]], [[4u3t]] – NgPBP 2 transpeptidase domain (mutant)<br /> | ||
| - | **[[5u2g]] – HiPBP 1A – ''Haemophilus influenza''<br /> | ||
| - | **[[3a3d]] – HiPBP 4 <br /> | ||
| - | **[[3a3j]] – HiPBP 5<br /> | ||
| - | **[[3lo7]], [[3un7]], [[5crf]] – MtPBP A – ''Mycobacterium tuberculosis''<br /> | ||
| - | **[[3oc2]], [[3pbn]], [[6hr4]] – PaPBP 3 – ''Pseudomonas aeruginosa''<br /> | ||
| - | **[[3tg9]] – PBP – ''Bacillus halodurans''<br /> | ||
| - | **[[3udf]] – AbPBP – ''Acinetobacter baumannii''<br /> | ||
| - | **[[3zg7]] – LmPBP 4 – ''Listeria monocytogenes''<br /> | ||
| - | **[[5dvy]], [[5e31]] – EfPBP 2 – ''Enterococcus faecium''<br /> | ||
| - | **[[6bsq]] - EfPBP 4<br /> | ||
| - | **[[6g0k]] - EfPBP 5 (mutant)<br /> | ||
| - | **[[5lp4]] – HpPBP 2 – ''Helicobacter pylor''i<br /> | ||
| - | |||
| - | *Penicillin-binding protein complex with antibiotics | ||
| - | |||
| - | **[[1qmf]], [[2z2m]], [[2zc3]], [[2zc4]], [[2zc5]], [[2zc6]], [[5oj1]], [[5oj0]], [[5oiz]] – SpPBP 2X + antibiotic<br /> | ||
| - | **[[1mwu]], [[1mwt]], [[1mws]] - SaPBP 2A (mutant) + antibiotic<br /> | ||
| - | **[[2uwx]] - SaPBP 1B (mutant) + antibiotic<br /> | ||
| - | **[[2olv]] - SaPBP 2 + antibiotic<br /> | ||
| - | **[[3zfz]], [[3zg0]], [[4dki]] - SaPBP 2’ + antibiotic<br /> | ||
| - | **[[3vsl]] - SaPBP 3 + antibiotic<br /> | ||
| - | **[[5txi]], [[5ty7]], [[5tw8]] - SaPBP 4 + antibiotic<br /> | ||
| - | **[[3hum]], [[3hun]], [[5ty2]], [[5tx9]], [[5tw4]] - SaPBP 4 (mutant) + antibiotic<br /> | ||
| - | **[[2c5w]] - SpPBP 1A + antibiotic<br /> | ||
| - | **[[2jch]], [[2je5]], [[2xd1]] - SpPBP 1B (mutant) + antibiotic<br /> | ||
| - | **[[2ex6]], [[2ex8]], [[2ex9]], [[2exa]], [[2exb]] - EcPBP 4 + antibiotic<br /> | ||
| - | **[[3beb]], [[3bec]], [[3mzd]], [[3mze]], [[3mzf]] - EcPBP 5 + antibiotic<br /> | ||
| - | **[[3ita]] - EcPBP 6 + antibiotic<br /> | ||
| - | **[[3fwl]], [[5hld]], [[5hlb]], [[5hla]], [[5hl9]] – EcPBP 1B + antibiotic<br /> | ||
| - | **[[3a3e]], [[3a3f]], [[3a3i]] – HiPBP 4 + antibiotic<br /> | ||
| - | **[[4oon]] – PaPBP 1A + antibiotic<br /> | ||
| - | **[[3ocl]], [[3ocn]], [[3pbo]], [[3pbq]], [[3pbr]], [[3pbs]], [[3pbt]], [[4kqo]], [[4kqq]], [[4kqr]], [[4l0l]], [[6un1]], [[6hr6]] – PaPBP 3 + antibiotic<br /> | ||
| - | **[[6hr9]] – PaPBP 3 (mutant) + antibiotic<br /> | ||
| - | **[[3nb6]], [[3nb7]] - AaPBP 1A + antibiotic<br /> | ||
| - | **[[3udi]], [[3udx]], [[3ue0]], [[3ue1]] - AbPBP + antibiotic<br /> | ||
| - | **[[3upn]], [[3upp]], [[5cxw]] - MtPBP A + antibiotic<br /> | ||
| - | **[[3upo]] - MtPBP A (mutant) + antibiotic<br /> | ||
| - | **[[3zg8]], [[3zg9]], [[3zga]] - LmPBP 4 + antibiotic<br /> | ||
| - | **[[6mkh]], [[6mki]], [[6bsr]] - EfPBP 4 + antibiotic<br /> | ||
| - | **[[6g88]] - EfPBP 5 + antibiotic<br /> | ||
| - | **[[6p54]], [[6p55]] – NgPBP 2 transpeptidase domain + antibiotic<br /> | ||
| - | |||
| - | *Penicillin-binding protein complex with boronic acid derivatives | ||
| - | |||
| - | **[[1z6f]] – EcPBP 5 + boronic acid<br /> | ||
| - | **[[2y2g]], [[2y2h]], [[2y2i]], [[2y2j]], [[2y2k]], [[2y2l]], [[2y2m]], [[2y2n]], [[2y2o]], [[2y2p]], [[2y2q]] - SpPBP 1B + boronic acid derivative | ||
| - | |||
| - | *Penicillin-binding protein complex with peptidoglycan | ||
| - | |||
| - | **[[3itb]] - EcPBP 6 + peptidoglycan peptide<br /> | ||
| - | **[[2j9p]] - BsPBP 4A + peptidoglycan peptide<br /> | ||
| - | **[[3zg5]] - SaPBP + peptidoglycan analog<br /> | ||
| - | |||
| - | *Penicillin-binding protein complex with other inhibitors | ||
| - | |||
| - | **[[4fsf]], [[4wel]], [[4wej]] - PaPBP 3 + inhibitor<br /> | ||
| - | **[[4wek]] – PaPBP 3 (mutant) + inhibitor<br /> | ||
| - | **[[5fgz]] – EcPBP 1B + inhibitor<br /> | ||
| - | **[[4cjn]] – SaPBP 2A + quinazolinine derivative<br /> | ||
| - | **[[6g9f]], [[6g9p]], [[6g9s]] – EcPBP 2 + inhibitor<br /> | ||
| - | **[[5lp5]] – HpPBP 2 + MREC <br /> | ||
| - | |||
| - | *PBP D-alanyl-D-alanine carboxypeptidase or DD-transpeptidase | ||
| - | |||
| - | **[[1skf]] – StDADC - Streptomyces<br /> | ||
| - | **[[1es2]], [[1es3]], [[1es4]], [[1es5]], [[1esi]], [[1j9m]] – StDADC (mutant) <br /> | ||
| - | **[[1w79]], [[1w8q]], [[1w8y]] – AcDADC - Actinomadura<br /> | ||
| - | **[[2wke]], [[4ben]] – AcDADC + antibiotic <br /> | ||
| - | **[[2xk1]], [[2xln]], [[2y4a]], [[2y55]], [[2y59]], [[3zvt]], [[3zvw]], [[4b4x]], [[4b4z]] – AcDADC + boronic acid derivative <br /> | ||
| - | **[[2vgj]], [[2vgk]], [[2xdm]] – AcDADC + peptidoglycan analog <br /> | ||
| - | **[[3zcz]] – AcDADC + inhibitor <br /> | ||
| - | **[[4rye]] – MtDADC <br /> | ||
| - | **[[4ppr]] – MtDACB1 + antibiotic <br /> | ||
| - | **[[5fsr]] – EcDADC <br /> | ||
| - | **[[5j8x]] – EcDACA + boronic acid derivative <br /> | ||
| - | **[[6ntz]] – EcDADC + antibiotic <br /> | ||
| - | **[[6osu]] – DADC – ''Francisella tularensis'' <br /> | ||
| - | |||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:31, 14 November 2019
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References
- ↑ Spratt BG. Distinct penicillin binding proteins involved in the division, elongation, and shape of Escherichia coli K12. Proc Natl Acad Sci U S A. 1975 Aug;72(8):2999-3003. PMID:1103132
- ↑ Beadle BM, Nicholas RA, Shoichet BK. Interaction energies between beta-lactam antibiotics and E. coli penicillin-binding protein 5 by reversible thermal denaturation. Protein Sci. 2001 Jun;10(6):1254-9. PMID:11369864 doi:http://dx.doi.org/10.1110/ps.52001
- ↑ Kishida H, Unzai S, Roper DI, Lloyd A, Park SY, Tame JR. Crystal structure of penicillin binding protein 4 (dacB) from Escherichia coli, both in the native form and covalently linked to various antibiotics. Biochemistry. 2006 Jan 24;45(3):783-92. PMID:16411754 doi:10.1021/bi051533t
