Neurotransmitters
From Proteopedia
(Difference between revisions)
(New page: <StructureSection load='' size='450' side='right' scene='Journal:JBSD:16/Cv/2' caption='Nicotinic Acetylcholine Receptor, PDB code 2bg9'> =Acetylcholine= [[Nicotinic Acetylcholine Rece...) |
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<StructureSection load='' size='450' side='right' scene='Journal:JBSD:16/Cv/2' caption='Nicotinic Acetylcholine Receptor, PDB code [[2bg9]]'> | <StructureSection load='' size='450' side='right' scene='Journal:JBSD:16/Cv/2' caption='Nicotinic Acetylcholine Receptor, PDB code [[2bg9]]'> | ||
=Acetylcholine= | =Acetylcholine= | ||
| - | [[Nicotinic Acetylcholine Receptor]] | + | [http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase] ([http://www.expasy.org/enzyme/3.1.1.7 EC 3.1.1.7], ''e.g.'' from [http://en.wikipedia.org/wiki/Pacific_electric_ray ''Torpedo californica''], ''Tc''AChE) [http://en.wikipedia.org/wiki/Hydrolysis hydrolysizes] the [http://en.wikipedia.org/wiki/Neurotransmitter neurotransmitter] [http://en.wikipedia.org/wiki/Acetylcholine acetylcholine] <scene name='2ace/Cv/2'>(ACh)</scene>, producing <scene name='2ace/Cv/3'>choline and an acetate</scene> group. ACh directly binds <scene name='2ace/Cv/4'>Ser200</scene> (via its [http://en.wikipedia.org/wiki/Nucleophile nucleophilic] Oγ atom) within the [http://en.wikipedia.org/wiki/Catalytic_triad catalytic triad] <scene name='2ace/Cv/5'>catalytic triad (Ser200, His440, and Glu327)</scene> of (ACh/''Tc''AChE structure [[2ace]]). The residues <scene name='2ace/Cv/6'>Trp84 and Phe330</scene> are also important in the [http://en.wikipedia.org/wiki/Ligand ligand] recognition. After this binding acetylcholinesterase <scene name='2ace/Cv/7'>hydrolysizes</scene> ACh. |
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| + | ==[[Nicotinic Acetylcholine Receptor]]== | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 15:29, 18 November 2019
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