Acetylcholine

Acetylcholinesterase (EC 3.1.1.7, e.g. from Torpedo californica, TcAChE) hydrolysizes the neurotransmitter acetylcholine , producing group. ACh directly binds (via its nucleophilic Oγ atom) within the catalytic triad of (ACh/TcAChE structure 2ace). The residues are also important in the ligand recognition. After this binding acetylcholinesterase ACh.

Acetylcholine Receptors

Nicotinic Acetylcholine Receptors

Nicotinic Acetylcholine Receptors in general

Binding site of AChR

Acetylcholine Receptor and its Reaction to Cobra Venom

Acetylcholinesterase

• Acetylcholinesterase: Treatment of Alzheimer's disease
  
• Torpedo californica acetylcholinesterase with bifunctional inhibitor
  
• Acetylcholinesterase: Substrate Traffic and Inhibition
  
• Acetylcholinesterase Inhibitor Pharmacokinetics
  
• Acetylcholinesterase inhibitors
  
• AChE inhibitors and substrates
  
• Human Acetylcholinesterase
  
• African Malaria Mosquito Acetylcholinesterase
  
• Acetylcholinesterase inhibited by nerve agent soman
  
• Acetylcholinesterase with DFP
  
• Acetylcholinesterase with OTMA
  
• Acetylcholinesterase with acetylcholine
  
• Acetylcholinesterase complexed with N-9-(1',2',3',4'-tetrahydroacridinyl)-1,8-diaminooctane
  
• Complex of TcAChE with an iminium galanthamine derivative
  
• Complex of TcAChE with bis-acting galanthamine derivative
  
• Cholinesterase
  
• Flexibility of aromatic residues in acetylcholinesterase
  
• Huperzine A Complexed with Acetylcholinesterase & Huperzine A Complexed with Acetylcholinesterase (Chinese)
  
• Acetylcholinesterase complexed with Tacrine, the 1st anti Alzheimer's drug
  
• Torpedo Californica Acetylcholinesterase in complex with an (R)-Tacrine-(10)-Hupyridone inhibitor
  
• Torpedo Californica Acetylcholinesterase in complex with an (S)-Tacrine-(10)-Hupyridone inhibitor
  
• Torpedo californica acetylcholinesterase with alkylene-linked tacrine dimer (5 carbon linker)
  
• Torpedo californica acetylcholinesterase with alkylene-linked tacrine dimer (7 carbon linker)
  
• Torpedo californica acetylcholinesterase with bifunctional inhibitor
  
• Tetramerization domain of acetylcholinesterase
  
• African Malaria Mosquito Acetylcholinesterase
• Group:SMART:Acetylcholinesterase:A Story of Substrate Traffic and Inhibition by Green Mamba Snake Toxin
  
• Treatments:AChE Inhibitor References
  

Alzheimer's Disease

Dopamine

DOPA decarboxylase

Dopamine Receptors

• Dopamine receptors 1 page
• Dopamine receptors 2 page