Sandbox GGC1
From Proteopedia
(Difference between revisions)
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== Function == | == Function == | ||
| - | The SAM domains form an octamer and play a part in axon degeneration. | + | SARM1 is a protein that contains SAM and TIR domains. SARM1 is involved in the cleavage of NAD+. The SAM domains form an octamer and play a part in axon degeneration by contributing to the enzymatic activity of TIR. |
== Disease == | == Disease == | ||
| - | + | The SAM domains are involved in Wallerian degeneration. In Wallerian degeneration, axons are degenerated following damage. This nerve damage can lead to neuropathic diseases. | |
== Relevance == | == Relevance == | ||
It's all relevant. | It's all relevant. | ||
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<scene name='75/752263/Area_of_interest/1'>TextToBeDisplayed</scene> | <scene name='75/752263/Area_of_interest/1'>TextToBeDisplayed</scene> | ||
== Structural highlights == | == Structural highlights == | ||
| - | + | The SAM domains need to form an octamer for SARM1 to be able to cleave NAD+. Five amino acids were found to be important for this to occur: Leu 442, Ile 461, Leu 514, Leu 531, and Val 533. If these amino acids were changed to arginine or aspartate, then NAD+ would no longer be able to be cleaved. <scene name='75/752263/Important_hydrophobic_residues/2'>ImportantAminoAcids</scene> <scene name='75/752263/Area_of_interest/1'>AreaOfInterest</scene> <scene name='75/752263/Close_up_hydrophobic_residues/2'>CloseUpOfAminoAcids</scene> | |
This is a '''sample''' scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a '''sample''' scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
| - | + | 1. Horsefield, S., Burdett, H., Zhang, X., Manik, M. K., Shi, Y., Chen, J., … Kobe, B. (2019). NAD cleavage activity by animal and plant TIR domains in cell death pathways. Science, 365(6455), 793–799. doi: 10.1126/science.aax1911 | |
Revision as of 08:08, 20 November 2019
Crystal structure of the tandem SAM domains from human SARM1
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References
1. Horsefield, S., Burdett, H., Zhang, X., Manik, M. K., Shi, Y., Chen, J., … Kobe, B. (2019). NAD cleavage activity by animal and plant TIR domains in cell death pathways. Science, 365(6455), 793–799. doi: 10.1126/science.aax1911
