Sandbox GGC3

Function

Myosin is a type of motor protein, which are proteins that specialize in turning Chemical Energy to mechanical Energy. The protein is commonly found in muscle tissue and is used for motility in eukaryotes. In order for the process to work, myosin uses the subdomains in its head to locate and attach to actin filaments.ATP is brought into the myosin active site, where ATPase hydrolyze the ATP to ADP+Pi.The hydrolyzing leads to tighter binding of the myosin and actin filament.The release of the Pi also leads to even tighter binding.The binding of myosin and actin filament forms what is known as muscle contraction or simply contractions.An additional ATP can be added to the structure to release the actin and have the cycle repeated.

Disease

Common disease related to myosin is Myopathy, which leads to muscle weakness. The is due to mutation of the MYH7 gene that synthesizes the long heavy chain. The mutation causes clumping of the myosin protein. The clumping stops the myosin from gathering filaments to create good contractions. The lack of this may be leading to the muscle weakness but it still unclear.

Relevance

Structural highlights

This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.