Sandbox GGC1

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SARM1 is a protein that contains SAM and TIR domains. SARM1 is involved in the cleavage of NAD+. The SAM domains form an octamer and play a part in axon degeneration by contributing to the enzymatic activity of TIR.
SARM1 is a protein that contains SAM and TIR domains. SARM1 is involved in the cleavage of NAD+. The SAM domains form an octamer and play a part in axon degeneration by contributing to the enzymatic activity of TIR.
== Disease ==
== Disease ==
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The SAM domains are involved in Wallerian degeneration. In Wallerian degeneration, axons are degenerated following damage. This nerve damage can lead to neuropathic diseases.
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The SAM domains are involved in Wallerian degeneration. In Wallerian degeneration, axons are degenerated following damage. This nerve damage can lead to neuropathic diseases. SARM1 causes cell death in plants also by cleaving NAD+.
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== Relevance ==
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It's all relevant.
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<scene name='75/752263/Important_hydrophobic_residues/2'>TextToBeDisplayed</scene>
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<scene name='75/752263/Close_up_hydrophobic_residues/2'>TextToBeDisplayed</scene>
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<scene name='75/752263/Area_of_interest/1'>TextToBeDisplayed</scene>
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== Structural highlights ==
== Structural highlights ==
The SAM domains need to form an octamer for SARM1 to be able to cleave NAD+. Five amino acids were found to be important for this to occur: Leu 442, Ile 461, Leu 514, Leu 531, and Val 533. If these amino acids were changed to arginine or aspartate, then NAD+ would no longer be able to be cleaved. <scene name='75/752263/Important_hydrophobic_residues/2'>ImportantAminoAcids</scene> <scene name='75/752263/Area_of_interest/1'>AreaOfInterest</scene> <scene name='75/752263/Close_up_hydrophobic_residues/2'>CloseUpOfAminoAcids</scene>
The SAM domains need to form an octamer for SARM1 to be able to cleave NAD+. Five amino acids were found to be important for this to occur: Leu 442, Ile 461, Leu 514, Leu 531, and Val 533. If these amino acids were changed to arginine or aspartate, then NAD+ would no longer be able to be cleaved. <scene name='75/752263/Important_hydrophobic_residues/2'>ImportantAminoAcids</scene> <scene name='75/752263/Area_of_interest/1'>AreaOfInterest</scene> <scene name='75/752263/Close_up_hydrophobic_residues/2'>CloseUpOfAminoAcids</scene>
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This is a '''sample''' scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
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</StructureSection>
</StructureSection>
== References ==
== References ==
1. Horsefield, S., Burdett, H., Zhang, X., Manik, M. K., Shi, Y., Chen, J., … Kobe, B. (2019). NAD cleavage activity by animal and plant TIR domains in cell death pathways. Science, 365(6455), 793–799. doi: 10.1126/science.aax1911
1. Horsefield, S., Burdett, H., Zhang, X., Manik, M. K., Shi, Y., Chen, J., … Kobe, B. (2019). NAD cleavage activity by animal and plant TIR domains in cell death pathways. Science, 365(6455), 793–799. doi: 10.1126/science.aax1911

Revision as of 08:15, 20 November 2019

Crystal structure of the tandem SAM domains from human SARM1

PDB ID 6O0S

Drag the structure with the mouse to rotate

References

1. Horsefield, S., Burdett, H., Zhang, X., Manik, M. K., Shi, Y., Chen, J., … Kobe, B. (2019). NAD cleavage activity by animal and plant TIR domains in cell death pathways. Science, 365(6455), 793–799. doi: 10.1126/science.aax1911

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