Sandbox GGC1
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
The SAM domains need to form an octamer for SARM1 to be able to cleave NAD+. Five amino acids were found to be important for this to occur: Leu 442, Ile 461, Leu 514, Leu 531, and Val 533. If these amino acids were changed to arginine or aspartate, then NAD+ would no longer be able to be cleaved. <scene name='75/752263/Important_hydrophobic_residues/2'>ImportantAminoAcids</scene> <scene name='75/752263/Area_of_interest/1'>AreaOfInterest</scene> <scene name='75/752263/Close_up_hydrophobic_residues/2'>CloseUpOfAminoAcids</scene> | The SAM domains need to form an octamer for SARM1 to be able to cleave NAD+. Five amino acids were found to be important for this to occur: Leu 442, Ile 461, Leu 514, Leu 531, and Val 533. If these amino acids were changed to arginine or aspartate, then NAD+ would no longer be able to be cleaved. <scene name='75/752263/Important_hydrophobic_residues/2'>ImportantAminoAcids</scene> <scene name='75/752263/Area_of_interest/1'>AreaOfInterest</scene> <scene name='75/752263/Close_up_hydrophobic_residues/2'>CloseUpOfAminoAcids</scene> | ||
| - | + | == Relevance == | |
| + | If the five amino acids in the SAM domains that help form the octamer are changed to arginine or asparagine, then it may be possible to inhibit the function of SARM1 and thus stop or slow down neuropathies. | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
1. Horsefield, S., Burdett, H., Zhang, X., Manik, M. K., Shi, Y., Chen, J., … Kobe, B. (2019). NAD cleavage activity by animal and plant TIR domains in cell death pathways. Science, 365(6455), 793–799. doi: 10.1126/science.aax1911 | 1. Horsefield, S., Burdett, H., Zhang, X., Manik, M. K., Shi, Y., Chen, J., … Kobe, B. (2019). NAD cleavage activity by animal and plant TIR domains in cell death pathways. Science, 365(6455), 793–799. doi: 10.1126/science.aax1911 | ||
Revision as of 08:18, 20 November 2019
Crystal structure of the tandem SAM domains from human SARM1
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References
1. Horsefield, S., Burdett, H., Zhang, X., Manik, M. K., Shi, Y., Chen, J., … Kobe, B. (2019). NAD cleavage activity by animal and plant TIR domains in cell death pathways. Science, 365(6455), 793–799. doi: 10.1126/science.aax1911
