This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Sandbox GGC12
From Proteopedia
| Line 5: | Line 5: | ||
== Structure == | == Structure == | ||
| - | The structure of the TBP has a pseudo-symmetry within its structure which contains two 88- amino acid repeats. This structure attaches to a DNA structure of deformity in the helix; the deformity is for the purpose of binding. The DNA structure's minor groove is open- wide to have complete access for the TBP to bind within it. | + | The structure of the TBP has a pseudo-symmetry within its structure which contains two 88- amino acid repeats. This structure attaches to a DNA structure of deformity in the helix; the deformity is for the purpose of binding. The DNA structure's minor groove is open- wide to have complete access for the TBP to bind within it (2). |
== Function == | == Function == | ||
| - | The TATA-Binding protein, TBP, is a factor in the process of Transcription within Eukaryotes. This binding protein is a subunit in the family of TFIID. The function of the TBP is to bind to a DNA sequence which is the TATA box. This allows RNA Polymerase II to bind to the promoter. This is the beginning of the process of Transcription. | + | The TATA-Binding protein, TBP, is a factor in the process of Transcription within Eukaryotes. This binding protein is a subunit in the family of TFIID. The function of the TBP is to bind to a DNA sequence which is the TATA box. This allows RNA Polymerase II to bind to the promoter. This is the beginning of the process of Transcription (1). |
== Relevance == | == Relevance == | ||
| Line 19: | Line 19: | ||
-The first ever for the TBP was found in fruit flies, specifically Drosophila flies. | -The first ever for the TBP was found in fruit flies, specifically Drosophila flies. | ||
| - | -This is not the same idea in prokaryotes. Prokaryotes have a different concept because it is a Pribnow box instead of a TATA box. | + | -This is not the same idea in prokaryotes. Prokaryotes have a different concept because it is a Pribnow box instead of a TATA box (2). |
| - | -Another name for the TATA box is the Goldberg- Hogness box. | + | -Another name for the TATA box is the Goldberg- Hogness box (1). |
| Line 38: | Line 38: | ||
== References == | == References == | ||
<references/> | <references/> | ||
| - | Kim, J., & Iyer, V. R. (2004). Global role of TATA box-binding protein recruitment to promoters in mediating gene expression profiles. Molecular and cellular biology, 24(18), 8104–8112. doi:10.1128/MCB.24.18.8104-8112.2004 | + | 1. Kim, J., & Iyer, V. R. (2004). Global role of TATA box-binding protein recruitment to promoters in mediating gene expression profiles. Molecular and cellular biology, 24(18), 8104–8112. doi:10.1128/MCB.24.18.8104-8112.2004 |
| - | Juo, Zong Sean, et al. “How Proteins Recognize the TATA Box.” Journal of Molecular Biology, vol. 261, no. 2, 1996, pp. 239–254., doi:10.1006/jmbi.1996.0456. | + | 2. Juo, Zong Sean, et al. “How Proteins Recognize the TATA Box.” Journal of Molecular Biology, vol. 261, no. 2, 1996, pp. 239–254., doi:10.1006/jmbi.1996.0456. |
Revision as of 13:35, 20 November 2019
TATA-Binding Protein (TBP)
| |||||||||||
References
1. Kim, J., & Iyer, V. R. (2004). Global role of TATA box-binding protein recruitment to promoters in mediating gene expression profiles. Molecular and cellular biology, 24(18), 8104–8112. doi:10.1128/MCB.24.18.8104-8112.2004
2. Juo, Zong Sean, et al. “How Proteins Recognize the TATA Box.” Journal of Molecular Biology, vol. 261, no. 2, 1996, pp. 239–254., doi:10.1006/jmbi.1996.0456.
