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== Function == | == Function == | ||
| - | The TATA-Binding protein, TBP, is a factor in the process of Transcription within Eukaryotes. This binding protein is a subunit in the family of TFIID. The function of the TBP is to bind to a DNA sequence which is the TATA box. This allows RNA Polymerase II to bind to the promoter. This is the beginning of the process of Transcription ( | + | The TATA-Binding protein, TBP, is a factor in the process of Transcription within Eukaryotes. This binding protein is a subunit in the family of TFIID. The function of the TBP is to bind to a DNA sequence which is the TATA box. This allows RNA Polymerase II to bind to the promoter. This is the beginning of the process of Transcription (3). |
== Relevance == | == Relevance == | ||
| - | The TATA-Binding Protein is relevant to everyday life because humans contain this specific protein as well with or without a promoter. This process is happening in multiple tissues and cells at a time. | + | The TATA-Binding Protein is relevant to everyday life because humans contain this specific protein as well with or without a promoter. This process is happening in multiple tissues and cells at a time (1). |
== Interesting Facts about the TBP == | == Interesting Facts about the TBP == | ||
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== References == | == References == | ||
<references/> | <references/> | ||
| - | 1. | + | |
| + | 1. Imbalzano, A., Kwon, H., Green, M. et al. Facilitated binding of TATA-binding protein to nucleosomal DNA. Nature 370, 481–485 (1994) doi:10.1038/370481a0 | ||
2. Juo, Zong Sean, et al. “How Proteins Recognize the TATA Box.” Journal of Molecular Biology, vol. 261, no. 2, 1996, pp. 239–254., doi:10.1006/jmbi.1996.0456. | 2. Juo, Zong Sean, et al. “How Proteins Recognize the TATA Box.” Journal of Molecular Biology, vol. 261, no. 2, 1996, pp. 239–254., doi:10.1006/jmbi.1996.0456. | ||
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| + | 3. Kim, J., & Iyer, V. R. (2004). Global role of TATA box-binding protein recruitment to promoters in mediating gene expression profiles. Molecular and cellular biology, 24(18), 8104–8112. doi:10.1128/MCB.24.18.8104-8112.2004 | ||
Revision as of 13:37, 20 November 2019
TATA-Binding Protein (TBP)
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References
1. Imbalzano, A., Kwon, H., Green, M. et al. Facilitated binding of TATA-binding protein to nucleosomal DNA. Nature 370, 481–485 (1994) doi:10.1038/370481a0
2. Juo, Zong Sean, et al. “How Proteins Recognize the TATA Box.” Journal of Molecular Biology, vol. 261, no. 2, 1996, pp. 239–254., doi:10.1006/jmbi.1996.0456.
3. Kim, J., & Iyer, V. R. (2004). Global role of TATA box-binding protein recruitment to promoters in mediating gene expression profiles. Molecular and cellular biology, 24(18), 8104–8112. doi:10.1128/MCB.24.18.8104-8112.2004
