Sandbox GGC12
From Proteopedia
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<StructureSection load='1tgh' size='340' side='right' caption='Caption for this structure' scene='78/781196/Tata_binding_protein/1''> | <StructureSection load='1tgh' size='340' side='right' caption='Caption for this structure' scene='78/781196/Tata_binding_protein/1''> | ||
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== Structure == | == Structure == | ||
| - | The structure of the TBP has a pseudo-symmetry within its structure which contains two 88- amino acid repeats. This structure attaches to a DNA structure of deformity in the helix; the deformity is for the purpose of binding. The DNA structure's minor groove is open | + | The structure of the <scene name='78/781196/Tata_binding_protein/1'>TATA-Binding Protein (TBP)</scene> has a pseudo-symmetry within its structure which contains two 88- amino acid repeats. This structure attaches to a DNA structure of deformity in the helix; the deformity is for the purpose of binding. The DNA structure's minor groove is wide open to have complete access for the TBP to bind within it (2). |
| - | = | + | <scene name='78/781196/Tata_binding_protein/1'>TATA-Binding Protein (TBP)</scene> |
| - | + | <scene name='78/781196/Tata-binding_protein/1'>Secondary Structures</scene> | |
| - | = | + | <scene name='78/781196/Inner_connections/1'>Inner Connections</scene> |
| - | + | <scene name='78/781196/Tbp_plus_tata_box/5'>Composition of Structure</scene> | |
| - | == Interesting Facts about the TBP == | ||
| - | + | == Function == | |
| - | - | + | The TATA-Binding protein, TBP, is a factor in the process of Transcription within Eukaryotes. This binding protein is a subunit in the family of TFIID. The function of the TBP is to bind to a DNA sequence which is the TATA box. This allows RNA Polymerase II to bind to the promoter. This is the beginning of the process of Transcription (3). |
| - | -Another name for the TATA box is the Goldberg- Hogness box (1). | ||
| + | == Relevance == | ||
| - | + | The TATA-Binding Protein is relevant to everyday life because humans contain this specific protein as well with or without a promoter. This process is happening in multiple tissues and cells at a time (1). Although it may not have any diseases | |
| + | connected with it, the protein is needed in everyday life. | ||
| - | <scene name='78/781196/Tata_binding_protein/1'>Original Structure</scene> | ||
| - | + | == Interesting Facts about the TBP == | |
| - | + | -The first ever for the TBP was found in fruit flies, specifically Drosophila flies. | |
| - | + | -This is not the same idea in prokaryotes. Prokaryotes have a different concept because it is a Pribnow box instead of a TATA box (2). | |
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| + | -Another name for the TATA box is the Goldberg-Hogness box (1). | ||
Revision as of 03:06, 28 November 2019
TATA-Binding Protein (TBP)
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References
1. Imbalzano, A., Kwon, H., Green, M. et al. Facilitated binding of TATA-binding protein to nucleosomal DNA. Nature 370, 481–485 (1994) doi:10.1038/370481a0
2. Juo, Zong Sean, et al. “How Proteins Recognize the TATA Box.” Journal of Molecular Biology, vol. 261, no. 2, 1996, pp. 239–254., doi:10.1006/jmbi.1996.0456.
3. Kim, J., & Iyer, V. R. (2004). Global role of TATA box-binding protein recruitment to promoters in mediating gene expression profiles. Molecular and cellular biology, 24(18), 8104–8112. doi:10.1128/MCB.24.18.8104-8112.2004
