6tdv
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of Euglena gracilis mitochondrial ATP synthase, membrane region== | |
| + | <StructureSection load='6tdv' size='340' side='right'caption='[[6tdv]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6tdv]] is a 38 chain structure with sequence from [http://en.wikipedia.org/wiki/Euglena_gracilis Euglena gracilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TDV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TDV FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=LPP:2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL+HEXADECANOATE'>LPP</scene>, <scene name='pdbligand=TRT:FRAGMENT+OF+TRITON+X-100'>TRT</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6tdv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tdv OCA], [http://pdbe.org/6tdv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tdv RCSB], [http://www.ebi.ac.uk/pdbsum/6tdv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tdv ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The mitochondrial ATP synthase fuels eukaryotic cells with chemical energy. Here we report the cryo-EM structure of a divergent ATP synthase dimer from mitochondria of Euglena gracilis, a member of the phylum Euglenozoa that also includes human parasites. It features 29 different subunits, 8 of which are newly identified. The membrane region was determined to 2.8 A resolution, enabling the identification of 37 associated lipids, including 25 cardiolipins, which provides insight into protein-lipid interaction and their functional roles. The rotor-stator interface comprises four membrane-embedded horizontal helices, including a distinct subunit a. The dimer interface is formed entirely by phylum-specific components, and a peripherally associated subcomplex contributes to the membrane curvature. The central and peripheral stalks directly interact with each other. Last, the ATPase inhibitory factor 1 (IF1) binds in a mode that is different from human, but conserved in Trypanosomatids. | ||
| - | + | Structure of a mitochondrial ATP synthase with bound native cardiolipin.,Muhleip A, McComas SE, Amunts A Elife. 2019 Nov 18;8. pii: 51179. doi: 10.7554/eLife.51179. PMID:31738165<ref>PMID:31738165</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 6tdv" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Euglena gracilis]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Amunts, A]] | ||
| + | [[Category: Muhleip, A]] | ||
| + | [[Category: Atp synthase]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Mitochondria]] | ||
Revision as of 07:00, 27 November 2019
Cryo-EM structure of Euglena gracilis mitochondrial ATP synthase, membrane region
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