3blg
From Proteopedia
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| - | [[Image:3blg.gif|left|200px]]<br /> | + | [[Image:3blg.gif|left|200px]]<br /><applet load="3blg" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="3blg" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="3blg, resolution 2.56Å" /> | caption="3blg, resolution 2.56Å" /> | ||
'''STRUCTURAL BASIS OF THE TANFORD TRANSITION OF BOVINE BETA-LACTOGLOBULIN FROM CRYSTAL STRUCTURES AT THREE PH VALUES; PH 6.2'''<br /> | '''STRUCTURAL BASIS OF THE TANFORD TRANSITION OF BOVINE BETA-LACTOGLOBULIN FROM CRYSTAL STRUCTURES AT THREE PH VALUES; PH 6.2'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 3BLG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. | + | 3BLG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Known structural/functional Site: <scene name='pdbsite=LOP:GLU 89 Is Involved In The Tanford Transition From The St ...'>LOP</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=3BLG OCA]. |
==Reference== | ==Reference== | ||
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[[Category: transport]] | [[Category: transport]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 20:38:23 2007'' |
Revision as of 18:28, 18 December 2007
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STRUCTURAL BASIS OF THE TANFORD TRANSITION OF BOVINE BETA-LACTOGLOBULIN FROM CRYSTAL STRUCTURES AT THREE PH VALUES; PH 6.2
Overview
The structures of the trigonal crystal form of bovine beta-lactoglobulin, variant A at pH 6.2, 7.1, and 8.2 have been determined by X-ray, diffraction methods at a resolution of 2.56, 2. 24, and 2.49 A, respectively. The corresponding values for R (Rfree) are 0.192 (0.240), 0.234 (0.279), and 0.232 (0.277). The C and N termini as well as two, disulfide bonds are clearly defined in these models. The glutamate side, chain of residue 89 is buried at pH 6.2 and becomes exposed at pH 7.1 and, 8.2. This conformational change, involving the loop 85-90, provides a, structural basis for a variety of pH-dependent chemical, physical, and, spectroscopic phenomena, collectively known as the Tanford transition.
About this Structure
3BLG is a Single protein structure of sequence from Bos taurus. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Structural basis of the Tanford transition of bovine beta-lactoglobulin., Qin BY, Bewley MC, Creamer LK, Baker HM, Baker EN, Jameson GB, Biochemistry. 1998 Oct 6;37(40):14014-23. PMID:9760236
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