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6tee
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of monooxygenase RutA under anaerobic conditions.== | |
| - | + | <StructureSection load='6tee' size='340' side='right'caption='[[6tee]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6tee]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TEE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TEE FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6sgg|6sgg]]</td></tr> |
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Oxidoreductase Oxidoreductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.46 1.14.99.46] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6tee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tee OCA], [http://pdbe.org/6tee PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tee RCSB], [http://www.ebi.ac.uk/pdbsum/6tee PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tee ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/RUTA_ECOLI RUTA_ECOLI]] Catalyzes the pyrimidine ring opening between N-3 and C-4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate. Requires the flavin reductase RutF to regenerate FMN in vivo. RutF can be substituted by Fre in vitro.<ref>PMID:16540542</ref> <ref>PMID:20400551</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Oxidoreductase]] | ||
| + | [[Category: Matthews, A]] | ||
| + | [[Category: Saleem-Batcha, R]] | ||
| + | [[Category: Teufel, R]] | ||
| + | [[Category: Bioengineering]] | ||
| + | [[Category: Flavin-n5-oxide]] | ||
| + | [[Category: Flavoprotein]] | ||
| + | [[Category: Fmn]] | ||
| + | [[Category: Monooxygenase]] | ||
| + | [[Category: Ruta]] | ||
Revision as of 08:10, 5 February 2020
Crystal structure of monooxygenase RutA under anaerobic conditions.
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