6tem
From Proteopedia
(Difference between revisions)
m (Protected "6tem" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==CENP-A nucleosome core particle with 145 base pairs of the Widom 601 sequence by cryo-EM== | |
| - | + | <StructureSection load='6tem' size='340' side='right'caption='[[6tem]], [[Resolution|resolution]] 3.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6tem]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TEM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TEM FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6tem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tem OCA], [http://pdbe.org/6tem PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tem RCSB], [http://www.ebi.ac.uk/pdbsum/6tem PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tem ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/H2B11_XENLA H2B11_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[http://www.uniprot.org/uniprot/CENPA_HUMAN CENPA_HUMAN]] Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro).<ref>PMID:20739937</ref> <ref>PMID:21478274</ref> [[http://www.uniprot.org/uniprot/H4_XENLA H4_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bednar, J]] | ||
| + | [[Category: Boopathi, R]] | ||
| + | [[Category: Danev, R]] | ||
| + | [[Category: Petosa, C]] | ||
| + | [[Category: Cenp-a nucleosome]] | ||
| + | [[Category: Dna binding protein]] | ||
| + | [[Category: Protein-dna complex]] | ||
Revision as of 06:55, 8 April 2020
CENP-A nucleosome core particle with 145 base pairs of the Widom 601 sequence by cryo-EM
| |||||||||||
