6abr

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:31, 27 March 2024) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='6abr' size='340' side='right'caption='[[6abr]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='6abr' size='340' side='right'caption='[[6abr]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[6abr]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ABR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ABR FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[6abr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ABR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ABR FirstGlance]. <br>
-
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6abr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6abr OCA], [http://pdbe.org/6abr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6abr RCSB], [http://www.ebi.ac.uk/pdbsum/6abr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6abr ProSAT]</span></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.002&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6abr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6abr OCA], [https://pdbe.org/6abr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6abr RCSB], [https://www.ebi.ac.uk/pdbsum/6abr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6abr ProSAT]</span></td></tr>
</table>
</table>
-
<div style="background-color:#fffaf0;">
+
== Function ==
-
== Publication Abstract from PubMed ==
+
[https://www.uniprot.org/uniprot/YFI6_YEAST YFI6_YEAST]
-
A multiprotein complex polarisome nucleates actin cables for polarized cell growth in budding yeast and filamentous fungi. However, the dynamic regulations of polarisome proteins in polymerizing actin under physiological and stress conditions remains unknown. We identify a previously functionally unknown polarisome member, actin-interacting-protein 5 (Aip5), which promotes actin assembly synergistically with formin Bni1. Aip5-C terminus is responsible for its activities by interacting with G-actin and Bni1. Through N-terminal intrinsically disordered region, Aip5 forms high-order oligomers and generate cytoplasmic condensates under the stresses conditions. The molecular dynamics and reversibility of Aip5 condensates are regulated by scaffolding protein Spa2 via liquid-liquid phase separation both in vitro and in vivo. In the absence of Spa2, Aip5 condensates hamper cell growth and actin cable structures under stress treatment. The present study reveals the mechanisms of actin assembly for polarity establishment and the adaptation in stress conditions to protect actin assembly by protein phase separation.
+
-
 
+
-
Polarisome scaffolder Spa2-mediated macromolecular condensation of Aip5 for actin polymerization.,Xie Y, Sun J, Han X, Tursic-Wunder A, Toh JDW, Hong W, Gao YG, Miao Y Nat Commun. 2019 Nov 7;10(1):5078. doi: 10.1038/s41467-019-13125-1. PMID:31699995<ref>PMID:31699995</ref>
+
-
 
+
-
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+
-
</div>
+
-
<div class="pdbe-citations 6abr" style="background-color:#fffaf0;"></div>
+
-
== References ==
+
-
<references/>
+
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Gao, Y G]]
+
[[Category: Saccharomyces cerevisiae S288C]]
-
[[Category: Hong, W]]
+
[[Category: Gao YG]]
-
[[Category: MIao, Y]]
+
[[Category: Hong W]]
-
[[Category: Sun, J]]
+
[[Category: MIao Y]]
-
[[Category: Toh, J D.W]]
+
[[Category: Sun J]]
-
[[Category: Xie, Y]]
+
[[Category: Toh JDW]]
-
[[Category: Structural protein]]
+
[[Category: Xie Y]]

Current revision

Actin interacting protein 5 (Aip5, wild type)

PDB ID 6abr

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6abr"
Personal tools