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143l

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[[Image:143l.gif|left|200px]]
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{{Seed}}
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[[Image:143l.png|left|200px]]
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{{STRUCTURE_143l| PDB=143l | SCENE= }}
{{STRUCTURE_143l| PDB=143l | SCENE= }}
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'''ROLE OF BACKBONE FLEXIBILITY IN THE ACCOMMODATION OF VARIANTS THAT REPACK THE CORE OF T4 LYSOZYME'''
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===ROLE OF BACKBONE FLEXIBILITY IN THE ACCOMMODATION OF VARIANTS THAT REPACK THE CORE OF T4 LYSOZYME===
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==Overview==
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To understand better how the packing of side chains within the core influences protein structure and stability, the crystal structures were determined for eight variants of T4 lysozyme, each of which contains three to five substitutions at adjacent interior sites. Concerted main-chain and side-chain displacements, with movements of helical segments as large as 0.8 angstrom, were observed. In contrast, the angular conformations of the mutated side chains tended to remain unchanged, with torsion angles within 20 degrees of those in the wild-type structure. These observations suggest that not only the rotation of side chains but also movements of the main chain must be considered in the evaluation of which amino acid sequences are compatible with a given protein fold.
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The line below this paragraph, {{ABSTRACT_PUBMED_8259514}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8259514 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8259514}}
==About this Structure==
==About this Structure==
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[[Category: Baldwin, E.]]
[[Category: Baldwin, E.]]
[[Category: Matthews, B W.]]
[[Category: Matthews, B W.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:30:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:29:48 2008''

Revision as of 12:29, 30 June 2008

Image:143l.png

Template:STRUCTURE 143l

ROLE OF BACKBONE FLEXIBILITY IN THE ACCOMMODATION OF VARIANTS THAT REPACK THE CORE OF T4 LYSOZYME

Template:ABSTRACT PUBMED 8259514

About this Structure

143L is a Single protein structure of sequence from Enterobacteria phage t4. Full crystallographic information is available from OCA.

Reference

The role of backbone flexibility in the accommodation of variants that repack the core of T4 lysozyme., Baldwin EP, Hajiseyedjavadi O, Baase WA, Matthews BW, Science. 1993 Dec 10;262(5140):1715-8. PMID:8259514

Page seeded by OCA on Mon Jun 30 15:29:48 2008

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