2bop

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<StructureSection load='2bop' size='340' side='right'caption='[[2bop]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='2bop' size='340' side='right'caption='[[2bop]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2bop]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BOP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2bop]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BOP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bop FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bop OCA], [http://pdbe.org/2bop PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bop RCSB], [http://www.ebi.ac.uk/pdbsum/2bop PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bop ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bop FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bop OCA], [https://pdbe.org/2bop PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bop RCSB], [https://www.ebi.ac.uk/pdbsum/2bop PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bop ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/VE2_BPV1 VE2_BPV1]] E2 regulates viral transcription and DNA replication. Binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. Can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication.
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[[https://www.uniprot.org/uniprot/VE2_BPV1 VE2_BPV1]] E2 regulates viral transcription and DNA replication. Binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. Can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 2bop" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2bop" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Regulatory protein E2|Regulatory protein E2]]
== References ==
== References ==
<references/>
<references/>

Revision as of 13:38, 13 October 2021

CRYSTAL STRUCTURE AT 1.7 ANGSTROMS OF THE BOVINE PAPILLOMAVIRUS-1 E2 DNA-BINDING DOMAIN BOUND TO ITS DNA TARGET

PDB ID 2bop

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