5cfl

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<StructureSection load='5cfl' size='340' side='right'caption='[[5cfl]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
<StructureSection load='5cfl' size='340' side='right'caption='[[5cfl]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5cfl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Nemve Nemve]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CFL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CFL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5cfl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Nematostella_vectensis Nematostella vectensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CFL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CFL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C2E:9,9-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d 3,2-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)'>C2E</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C2E:9,9-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d 3,2-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)'>C2E</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5cfm|5cfm]], [[5cfn|5cfn]], [[5cfo|5cfo]], [[5cfp|5cfp]], [[5cfq|5cfq]], [[5cfr|5cfr]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cfl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cfl OCA], [https://pdbe.org/5cfl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cfl RCSB], [https://www.ebi.ac.uk/pdbsum/5cfl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cfl ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">v1g246111 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=45351 NEMVE])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cfl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cfl OCA], [http://pdbe.org/5cfl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cfl RCSB], [http://www.ebi.ac.uk/pdbsum/5cfl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cfl ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/STING_NEMVE STING_NEMVE] Sensor of cytosolic DNA from bacteria and viruses that promotes autophagy (PubMed:30842662). Acts by recognizing and binding cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA in the cytosol (PubMed:26300263, PubMed:30842662). Following cGAMP-binding, promotes the formation of autophagosomes, leading to target cytosolic DNA for degradation by the lysosome (PubMed:30842662). Exhibits guanine base-specific ligand recognition. Binds 3'-3'linked cGAMP, 2'-3' linked cGAMP and 3'-3' linked c-di-GMP with much greater affinity as compared to 3'-3' linked c-di-AMP (PubMed:26300263). Lacks the C-terminal tail (CTT) found in mammalian orthologs which is essential for interferon signaling (PubMed:26300263).<ref>PMID:26300263</ref> <ref>PMID:30842662</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Stimulator of interferon genes|Stimulator of interferon genes]]
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*[[Stimulator of interferon genes protein|Stimulator of interferon genes protein]]
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*[[Stimulator of interferon genes protein 3D structures|Stimulator of interferon genes protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Nemve]]
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[[Category: Nematostella vectensis]]
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[[Category: Berger, J M]]
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[[Category: Berger JM]]
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[[Category: Doudna, J A]]
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[[Category: Doudna JA]]
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[[Category: Kranzusch, P J]]
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[[Category: Kranzusch PJ]]
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[[Category: Lee, A S.Y]]
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[[Category: Lee ASY]]
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[[Category: Vance, R E]]
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[[Category: Vance RE]]
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[[Category: Wilson, S C]]
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[[Category: Wilson SC]]
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[[Category: Cyclic-dinucleotide binding domain]]
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[[Category: Immune system]]
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[[Category: Sting]]
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Revision as of 12:03, 14 June 2023

Crystal structure of anemone STING (Nematostella vectensis) in complex with 3', 3' c-di-GMP, c[G(3', 5')pG(3', 5')p]

PDB ID 5cfl

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