5ds4

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Current revision (21:57, 28 June 2023) (edit) (undo)
 
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<StructureSection load='5ds4' size='340' side='right'caption='[[5ds4]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<StructureSection load='5ds4' size='340' side='right'caption='[[5ds4]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ds4]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DS4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DS4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ds4]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Escherichia_virus_M13 Escherichia virus M13]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DS4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DS4 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4p6i|4p6i]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ygbT, cas1, b2755, JW2725 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI]), ygbF, cas2, b2754, JW5438 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ds4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ds4 OCA], [https://pdbe.org/5ds4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ds4 RCSB], [https://www.ebi.ac.uk/pdbsum/5ds4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ds4 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ds4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ds4 OCA], [http://pdbe.org/5ds4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ds4 RCSB], [http://www.ebi.ac.uk/pdbsum/5ds4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ds4 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CAS1_ECOLI CAS1_ECOLI]] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Cas1 is thought to be involved in CRISPR adaptation, the first stage of CRISPR immunity. Might be involved in the addition/removal of CRISPR spacers. Endonucleolytically cleaves linear ssRNA, ssDNA and short (34 base) dsDNA as well as branched DNA substrates such as Holliday junctions, replication forks and 5'-flap DNA substrates. Genetic interactions suggest Cas1 interacts with components of the RecBC and RuvB DNA repair systems.<ref>PMID:21255106</ref> [[http://www.uniprot.org/uniprot/CAS2_ECOLI CAS2_ECOLI]] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity).<ref>PMID:21255106</ref>
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[https://www.uniprot.org/uniprot/CAS2_ECOLI CAS2_ECOLI] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity).<ref>PMID:21255106</ref>
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ecoli]]
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[[Category: Escherichia coli K-12]]
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[[Category: Escherichia virus M13]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Doudna, J A]]
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[[Category: Doudna JA]]
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[[Category: Engelman, A N]]
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[[Category: Engelman AN]]
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[[Category: Harrington, L B]]
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[[Category: Harrington LB]]
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[[Category: Kranzusch, P J]]
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[[Category: Kranzusch PJ]]
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[[Category: Nunez, J K]]
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[[Category: Nunez JK]]
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[[Category: Clustered regularly interspaced short palindromic repeat]]
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[[Category: Crispr-cas system]]
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[[Category: Dna binding protein]]
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[[Category: Endodeoxyribonuclease]]
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[[Category: Endonuclease]]
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[[Category: Hydrolase-dna complex]]
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[[Category: Integrase]]
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Current revision

Crystal structure the Escherichia coli Cas1-Cas2 complex bound to protospacer DNA

PDB ID 5ds4

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