153d

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:153d.gif|left|200px]]
+
{{Seed}}
 +
[[Image:153d.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_153d| PDB=153d | SCENE= }}
{{STRUCTURE_153d| PDB=153d | SCENE= }}
-
'''CRYSTAL STRUCTURE OF A MISPAIRED DODECAMER, D(CGAGAATTC(O6ME)GCG)2, CONTAINING A CARCINOGENIC O6-METHYLGUANINE'''
+
===CRYSTAL STRUCTURE OF A MISPAIRED DODECAMER, D(CGAGAATTC(O6ME)GCG)2, CONTAINING A CARCINOGENIC O6-METHYLGUANINE===
-
==Overview==
+
<!--
-
The crystal structure of the synthetic deoxydodecamer d(CGAGAATTC(O6Me)GCG)2 has been determined and refined to an R-factor of 16.9% with data up to 2.9-A resolution. This sequence contains two mismatched base pairs between O6-methylguanine and adenine with the arrangement A(syn).(O6-Me)G(anti) which differs from the geometry observed in solution by NMR. The intermolecular arrangement is equivalent to the other isomorphous deoxydodecamers. However, the weakening of some significant crystal packing contacts was observed and related to the effect of stacking between the mispaired adenine and the adjacent guanine in the sequence. The structure is highly hydrated, with a total of 49 solvent molecules located. The methyl group and the mismatched base-pair geometry locally disrupt the B-DNA-type solvent network with two solvent molecules found close to the N1 and N6 of the mispaired adenine.
+
The line below this paragraph, {{ABSTRACT_PUBMED_8142345}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 8142345 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_8142345}}
==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Mismatched]]
[[Category: Mismatched]]
[[Category: Modified]]
[[Category: Modified]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:31:00 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:31:43 2008''

Revision as of 12:31, 30 June 2008

Image:153d.png

Template:STRUCTURE 153d

CRYSTAL STRUCTURE OF A MISPAIRED DODECAMER, D(CGAGAATTC(O6ME)GCG)2, CONTAINING A CARCINOGENIC O6-METHYLGUANINE

Template:ABSTRACT PUBMED 8142345

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of a mispaired dodecamer, d(CGAGAATTC(O6Me)GCG)2, containing a carcinogenic O6-methylguanine., Ginell SL, Vojtechovsky J, Gaffney B, Jones R, Berman HM, Biochemistry. 1994 Mar 29;33(12):3487-93. PMID:8142345

Page seeded by OCA on Mon Jun 30 15:31:43 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/153d"
Personal tools