159d

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[[Image:159d.gif|left|200px]]
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{{STRUCTURE_159d| PDB=159d | SCENE= }}
{{STRUCTURE_159d| PDB=159d | SCENE= }}
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'''SIDE BY SIDE BINDING OF TWO DISTAMYCIN A DRUGS IN THE MINOR GROOVE OF AN ALTERNATING B-DNA DUPLEX'''
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===SIDE BY SIDE BINDING OF TWO DISTAMYCIN A DRUGS IN THE MINOR GROOVE OF AN ALTERNATING B-DNA DUPLEX===
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==Overview==
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Here we report the 1.8A X-ray structure of a 2:1 drug-DNA complex between distamycin A and an alternating B-DNA octamer duplex d(ICICICIC)2. The two distamycin A molecules are bound side by side with dyad symmetry in an antiparallel orientation in the expanded minor groove. The amides of each drug molecule are hydrogen bonded to the minor groove base atoms of only one DNA strand. The complex not only shows binding of two drug molecules, but the DNA duplex also exhibits striking low-high alternations in the helical twist angles, the sugar puckering and the phosphate conformations, providing the basis for a new model for an alternating B-DNA with a dinucleotide repeat.
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The line below this paragraph, {{ABSTRACT_PUBMED_7656035}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7656035 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7656035}}
==About this Structure==
==About this Structure==
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[[Category: Double helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:31:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:32:55 2008''

Revision as of 12:33, 30 June 2008

Image:159d.png

Template:STRUCTURE 159d

SIDE BY SIDE BINDING OF TWO DISTAMYCIN A DRUGS IN THE MINOR GROOVE OF AN ALTERNATING B-DNA DUPLEX

Template:ABSTRACT PUBMED 7656035

About this Structure

Full crystallographic information is available from OCA.

Reference

Binding of two distamycin A molecules in the minor groove of an alternating B-DNA duplex., Chen X, Ramakrishnan B, Rao ST, Sundaralingam M, Nat Struct Biol. 1994 Mar;1(3):169-75. PMID:7656035

Page seeded by OCA on Mon Jun 30 15:32:55 2008

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