1ncv

From Proteopedia

(Difference between revisions)

Revision as of 07:01, 25 August 2021

DETERMINATION CC-CHEMOKINE MCP-3, NMR, 7 STRUCTURES

Structural highlights

1ncv is a 2 chain structure with sequence from Human. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[CCL7_HUMAN] Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

MCP-3 is a beta chemokine consisting of 76 amino acid residues. It has been described to be involved in the activation of all leukocytic cells, activation mediated by the presence of multiple binding sites on the target cells. Its three-dimensional structure has been studied by making use of two-dimensional 1H NMR spectroscopy. MCP-3 exhibits the same monomeric structure as the other chemokines, i.e., a three-stranded antiparallel beta sheet covered on one face by an alpha helix. Although it belongs to the same subfamily as RANTES (Chung et al., 1995; Faitbrother et al., 1994) and hMIP-1beta (Lodi et al., 1994), the MCP-3 dimer is folded like IL-8 with the so-called alphabeta sandwich structural motif. Structural and sequence analysis gives clear indications suggesting that the other MCP chemokines may have the same quaternary structure, contrary to the other beta chemokines.

Determination of the three-dimensional structure of CC chemokine monocyte chemoattractant protein 3 by 1H two-dimensional NMR spectroscopy.,Meunier S, Bernassau JM, Guillemot JC, Ferrara P, Darbon H Biochemistry. 1997 Apr 15;36(15):4412-22. PMID:9109648^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Meunier S, Bernassau JM, Guillemot JC, Ferrara P, Darbon H. Determination of the three-dimensional structure of CC chemokine monocyte chemoattractant protein 3 by 1H two-dimensional NMR spectroscopy. Biochemistry. 1997 Apr 15;36(15):4412-22. PMID:9109648 doi:10.1021/bi9627929

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ncv"

@@ Line 3: / Line 3: @@
 <StructureSection load='1ncv' size='340' side='right'caption='[[1ncv]], [[NMR_Ensembles_of_Models | 7 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1ncv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NCV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NCV FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1ncv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NCV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NCV FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ncv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ncv OCA], [http://pdbe.org/1ncv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ncv RCSB], [http://www.ebi.ac.uk/pdbsum/1ncv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ncv ProSAT]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ncv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ncv OCA], [https://pdbe.org/1ncv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ncv RCSB], [https://www.ebi.ac.uk/pdbsum/1ncv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ncv ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/CCL7_HUMAN CCL7_HUMAN]] Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3.
+[[https://www.uniprot.org/uniprot/CCL7_HUMAN CCL7_HUMAN]] Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 30: / Line 30: @@
 ==See Also==
 *[[Monocyte chemoattractant protein|Monocyte chemoattractant protein]]
-*[[User:Coline Perrin/CCL2|User:Coline Perrin/CCL2]]
 == References ==
 <references/>

1ncv

From Proteopedia

Revision as of 07:01, 25 August 2021

DETERMINATION CC-CHEMOKINE MCP-3, NMR, 7 STRUCTURES

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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