1oct

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<StructureSection load='1oct' size='340' side='right'caption='[[1oct]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='1oct' size='340' side='right'caption='[[1oct]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1oct]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OCT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OCT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1oct]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OCT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OCT FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oct OCA], [http://pdbe.org/1oct PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1oct RCSB], [http://www.ebi.ac.uk/pdbsum/1oct PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1oct ProSAT]</span></td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oct OCA], [https://pdbe.org/1oct PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oct RCSB], [https://www.ebi.ac.uk/pdbsum/1oct PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oct ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PO2F1_HUMAN PO2F1_HUMAN]] Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.<ref>PMID:1684878</ref>
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[[https://www.uniprot.org/uniprot/PO2F1_HUMAN PO2F1_HUMAN]] Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.<ref>PMID:1684878</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 1oct" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1oct" style="background-color:#fffaf0;"></div>
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==See Also==
 
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*[[Intrinsically Disordered Protein|Intrinsically Disordered Protein]]
 
== References ==
== References ==
<references/>
<references/>

Revision as of 07:11, 25 August 2021

CRYSTAL STRUCTURE OF THE OCT-1 POU DOMAIN BOUND TO AN OCTAMER SITE: DNA RECOGNITION WITH TETHERED DNA-BINDING MODULES

PDB ID 1oct

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