1neb
From Proteopedia
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<StructureSection load='1neb' size='340' side='right'caption='[[1neb]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''> | <StructureSection load='1neb' size='340' side='right'caption='[[1neb]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[1neb]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1neb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NEB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NEB FirstGlance]. <br> |
- | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1neb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1neb OCA], [https://pdbe.org/1neb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1neb RCSB], [https://www.ebi.ac.uk/pdbsum/1neb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1neb ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
- | [[ | + | [[https://www.uniprot.org/uniprot/NEBU_HUMAN NEBU_HUMAN]] Defects in NEB are the cause of nemaline myopathy type 2 (NEM2) [MIM:[https://omim.org/entry/256030 256030]]. A form of nemaline myopathy. Nemaline myopathies are muscular disorders characterized by muscle weakness of varying severity and onset, and abnormal thread-or rod-like structures in muscle fibers on histologic examination.<ref>PMID:10051637</ref> |
== Function == | == Function == | ||
- | [[ | + | [[https://www.uniprot.org/uniprot/NEBU_HUMAN NEBU_HUMAN]] This giant muscle protein may be involved in maintaining the structural integrity of sarcomeres and the membrane system associated with the myofibrils. Binds and stabilize F-actin. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] |
Revision as of 07:01, 25 August 2021
SH3 DOMAIN FROM HUMAN NEBULIN, NMR, MINIMIZED AVERAGE STRUCTURE
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Categories: Human | Large Structures | Pastore, A | Politou, A S | Actin-binding | Nebulin | Sh3 domain | Z-disk