Phosphoribosyltransferase

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Yeast orotate phosphoribosyltransferase dimer complex with orotate and PRPP (PDB entry 2ps1)

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1 Function
2 Disease
3 Relevance
4 Structural highlights
5 3D structures of phosphoribosyltransferase

Function

Phosphoribosyltransferase (PRT) are transferases which belong to several classes:
1. Hypoxanthine-guanine PRT (HPRT). HPRT is part of the purine biosynthesis and catalyzes the formation of GMP from guanine, xanthosine monophosphate from xanthosine and of IMP from hypoxanthine and phosphoribosyl pyrophosphate (PRPP)^[1].
2. Orotate PRT (OPRT). OPRT is part of the pyrimidine biosynthesis and catalyzes the formation of orotidine 5’-monophosphate (OMP) from orotate and phosphoribosyl pyrophosphate (PRPP)^[2].
3. Quinolinic acid PRT (QAPRT ). QAPRT is a degrading enzyme found in the brain^[3].
4. Uracil PRT (UPRT). UPRT catalyzes the formation of UMP from uracil and PRPP. Adenine PRT (APRT). APRT catalyzes the formation of AMP from adenine and PRPP^[4].
5. Nicotinate nucleotide dimethylbenzimidazole PRT (NN:DBI PRT). NN:DBI PRT is part of riboflavin, porphyrin and chlorophyll biosynthesis^[5].
6. Anthranilate PRT (ANPRT). ANPRT participates in phenylalanine, tyrosine and tryptophan biosynthesis and catalyzes the formation of anthraniline from phosphoribosyl anthranilate^[6].
7. ATP PRT participates in histidine biosynthesis and catalyzes the formation of ATP from phosphoribosyl ATP and diphosphate^[7]. See ATP Phosphoribosyl Transferase.
8. Nicotinate PRT (NIPRT). NIPRT catalyzes the formation of nicotinate from nicotinate ribonucleotide and diphosphate^[8].
9. Nicotinamide PRT (NMPRT). NMPRT catalyzes the formation of nicotinamide from nicotinamide ribonucleotide (NMN) and diphosphate^[9].

Disease

Mutations in HPRT are involved in Lesch-Nyhan syndrome and hereditary gout^[10].

Relevance

NMPRT inhibition is a target in controlling inflammation disorders^[11].

Structural highlights

The structure of the yeast OPRT contains the two reaction products: and ^[2]. . Water molecules are shown as red spheres. .

3D structures of phosphoribosyltransferase

Phosphoribosyltransferase 3D structures

References

↑ Sculley DG, Dawson PA, Emmerson BT, Gordon RB. A review of the molecular basis of hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency. Hum Genet. 1992 Nov;90(3):195-207. PMID:1487231
↑ ^2.0 ^2.1 Gonzalez-Segura L, Witte JF, McClard RW, Hurley TD. Ternary complex formation and induced asymmetry in orotate phosphoribosyltransferase. Biochemistry. 2007 Dec 11;46(49):14075-86. Epub 2007 Nov 20. PMID:18020427 doi:10.1021/bi701023z
↑ Foster AC, Whetsell WO Jr, Bird ED, Schwarcz R. Quinolinic acid phosphoribosyltransferase in human and rat brain: activity in Huntington's disease and in quinolinate-lesioned rat striatum. Brain Res. 1985 Jun 17;336(2):207-14. PMID:3159462
↑ Carter D, Donald RG, Roos D, Ullman B. Expression, purification, and characterization of uracil phosphoribosyltransferase from Toxoplasma gondii. Mol Biochem Parasitol. 1997 Aug;87(2):137-44. PMID:9247925
↑ . PMID:121011881
↑ Castell A, Short FL, Evans GL, Cookson TV, Bulloch EM, Joseph DD, Lee CE, Parker EJ, Baker EN, Lott JS. Substrate capture mechanism of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase provides a mode for inhibition. Biochemistry. 2013 Jan 30. PMID:23363292 doi:http://dx.doi.org/10.1021/bi301387m
↑ Pedreno S, Pisco JP, Larrouy-Maumus G, Kelly G, de Carvalho LP. Mechanism of feedback allosteric inhibition of ATP phosphoribosyltransferase. Biochemistry. 2012 Oct 9;51(40):8027-38. doi: 10.1021/bi300808b. Epub 2012 Sep, 27. PMID:22989207 doi:http://dx.doi.org/10.1021/bi300808b
↑ Galassi L, Di Stefano M, Brunetti L, Orsomando G, Amici A, Ruggieri S, Magni G. Characterization of human nicotinate phosphoribosyltransferase: Kinetic studies, structure prediction and functional analysis by site-directed mutagenesis. Biochimie. 2012 Feb;94(2):300-9. doi: 10.1016/j.biochi.2011.06.033. Epub 2011 Jul, 3. PMID:21742010 doi:http://dx.doi.org/10.1016/j.biochi.2011.06.033
↑ Imai S. Nicotinamide phosphoribosyltransferase (Nampt): a link between NAD biology, metabolism, and diseases. Curr Pharm Des. 2009;15(1):20-8. PMID:19149599
↑ Tohyama J, Nanba E, Ohno K. Hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency: identification of point mutations in Japanese patients with Lesch-Nyhan syndrome and hereditary gout and their permanent expression in an HPRT-deficient mouse cell line. Hum Genet. 1994 Feb;93(2):175-81. PMID:8112742
↑ Montecucco F, Cea M, Cagnetta A, Damonte P, Nahimana A, Ballestrero A, Del Rio A, Bruzzone S, Nencioni A. Nicotinamide phosphoribosyltransferase as a target in inflammation- related disorders. Curr Top Med Chem. 2013;13(23):2930-8. PMID:24171767

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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Phosphoribosyltransferase

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Contents

Function

Disease

Relevance

Structural highlights

3D structures of phosphoribosyltransferase

References

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@@ Line 26: / Line 26: @@
 </StructureSection>
-==3D structures of phosphoribosyltransferase==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*'''Orotate phosphoribosyltransferase'''
-**[[2pry]] - yOPRT – yeast<br />
-**[[1oro]] - EcOPRT – ''Escherichia coli''<br />
-**[[1j7j]] - StOPRT – ''Salmonella typhimurium''<br />
-**[[2aee]] - OPRT – ''Streptococcus pyogenes''<br />
-**[[3dez]] - OPRT – ''Streptococcus mutans''<br />
-**[[2yzk]] – OPRT – ''Aeropyrum pernix''<br />
-**[[3m3h]] - BaOPRT – ''Bacillus anthracis''<br />
-**[[3mjd]] - OPRT – ''Francisella tularensis''<br />
-**[[3n2l]] - VcOPRT – ''Vibrio cholera''<br />
-**[[3qw3]], [[3qw4]] - OPRT – ''Leishmania infantum''<br />
-**[[2p1z]] – OPRT – ''Corynebacterium diphtheriae''<br />
-**[[4fym]] - PfOPRT – ''Plasmodium falciparum''<br />
-**[[4ohc]] – OPRT – ''Burkholderia cenocepacia''<br />
-**[[4paw]] – HpOPRT  – ''Helicobacter pylori''<br />
-*Orotate phosphoribosyltransferase complex
-**[[2qcn]], [[2wns]], [[3l0k]], [[3l0n]], [[3mo7]] – hOPRT + UMP derivative<br />
-**[[3mi2]] - hOPRT + pyrazofurin monophosphate<br />
-**[[4hib]], [[4hkp]] - hOPRT + inhibitor<br />
-**[[2prz]] - yOPRT + OMP<br />
-**[[4wml]], [[4wn3]] - yOPRT + PRPP<BR />
-**[[2ps1]] - yOPRT + orotate + PRPP<BR />
-**[[1sto]] – StOPRT + OMP<br />
-**[[4rv4]] - BaOPRT + PRPP<BR />
-**[[1opr]], [[1lh0]] - StOPRT + orotate + PRPP<BR />
-**[[5hki]] – MtOPRT + Fe-citrate – ''Mycobacterium tuberculosis''  <br />
-**[[5hkf]] - MtOPRT + PRPP<BR />
-**[[5hkl]] - MtOPRT (mutant) + Pi<BR />
-*'''Hypoxanthine-guanine phosphoribosyltransferase'''
-**[[1z7g]] - hHPRT <br />
-**[[1nul]], [[1grv]] - EcHPRT <br />
-**[[1dbr]] - TgHPRT – ''Toxoplasma gondii''<br />
-**[[1tc1]] - TcHPRT – ''Trypanosoma cruzi''<br />
-**[[1r3u]] - TteHPRT – ''Thermoanaerobacter tengongensis''<br />
-**[[2geb]] - TteHPRT (mutant) <br />
-**[[1vdm]] - PhHPRT – ''Pyrococcus horikoshii''<br />
-**[[3h83]], [[3hvu]], [[3o7m]], [[4qyi]] - BaHPRT<br />
-**[[3acb]] - TtHPRT – ''Thermus thermophilus''<br />
-**[[3ohp]] - VcHPRT 	<br />
-**[[4lyy]] – HPRT – ''Shewanella pealeana''<br />
-**[[4pfq]] – HPRT – ''Brachybacterium faecium''<br />
-**[[4qri]] – HPRT – ''Leptospira interrogans''<br />
-**[[4rqa]], [[4rqb]] – HPRT – ''Staphylococcus aureus''<br />
-**[[5xtk]], [[6kp5]] – YpeHGPRT – ''Yersinia pestis''<br />
-**[[6kqc]] - YpeHGPRT (mutant) <br />
-**[[5esw]] - LpHGPRT – ''Legionella pneumophila''<BR />
-**[[6igs]] - FtHGPRT 	<br />
-**[[6d9q]] - BaHGPRT<br />
-*Hypoxanthine-guanine phosphoribosyltransferase binary complex with nucleotide
-**[[1hmp]] - hHGPRT + GMP - human<br />
-**[[3gep]], [[3ggj]], [[4jit]], [[4jls]] - hHGPRT + guanine derivative<br />
-**[[2jky]], [[2jkz]], [[2xbu]] - yHGPRT + GMP<br />
-**[[1a98]], [[1a97]] - EcHGPRT (mutant) + GMP<br />
-**[[1g9s]] - EcHGPRT + IMP<BR />
-**[[1g9t]] - EcHGPRT  + GMP<br />
-**[[5knx]], [[5knv]], [[5knu]], [[5knt]], [[5kns]], [[5knr]] - EcHGPRT + nucleoside phosphonate<br />
-**[[1hgx]] - HGPRT + GMP – ''Tritrichomonas foetus''<br />
-**[[1qk3]] - TgHGPRT + GMP<br />
-**[[1qk4]] - TgHGPRT + IMP<BR />
-**[[1p19]] - TcHGPRT + IMP<BR />
-**[[1p17]] - TcHGPRT (mutant) + IMP<BR />
-**[[1yfz]] - TteHGPRT + IMP<BR />
-**[[1pzm]] - LtHGPRT + GMP – ''Leishmania tarentolae''<br />
-**[[1y0b]] - BsHGPRT + GTP – ''Bacillus subtilis''<br />
-**[[2fxv]] - BsHGPRT + GMP<br />
-**[[3kb8]] - BaHGPRT + GMP<br />
-**[[6d9s]] - BaHGPRT + PPGPP<br />
-**[[3acc]] - TtHGPRT + GMP<br />
-**[[3acd]] - TtHGPRT + IMP<BR />
-**[[1d6n]] - LdAPRT + AMP derivative<br />
-**[[4zfn]] - SsHGPRT + GMP<br />
-**[[5kam]] - TbHGPRT + IMP - Trypanosoma brucei <BR />
-**[[5jv5]], [[6mxc]] - TbHGPRT + GMP<BR />
-**[[6mxb]], [[6mxg]] - TbHGPRT + XMP<BR />
-**[[6mxd]] - TbHGPRT + IMP<BR />
-**[[5ipf]] - HGPRT + IMP – Schistosoma mansoni<BR />
-**[[5esx]] - LpHGPRT + GMP <BR />
-==Hypoxanthine-guanine PRT binary complex ==
-**[[3ggc]] - hHGPRT + hypoxanthine derivative<br />
-**[[4ijq]], [[4rab]], [[4rac]], [[4rad]], [[4ran]], [[4rao]], [[4raq]], [[6bnj]], **[[5w8v]], [[5hia]] - hHGPRT + inhibitor<br />
-**[[5bsk]], [[5brn]] - hHGPRT (mutant) + nucleoside phosphonate <br />
-**[[4kn6]] - hHGPRT + antiviral agent<br />
-**[[1dqp]] - GiHGPRT + imucillin – ''Giardia intestinalis''<br />
-**[[3ozf]] - PfHGPRT + hypoxanthine<br />
-**[[3ozg]] - PfHGPRT + inhibitor<br />
-**[[5kny]] - MtHGPRT + inhibitor<br />
-**[[4rhx]], [[4rhu]], [[4rht]] - MtHGPRT + nucleoside phosphonate <br />
-**[[1dqn]] - GiHGPRT + transition state analog<br />
-**[[4z1o]] - SsHGPRT + PRPP - Sulfolobus solfataricus<br />
-**[[6bo7]] - HGPRT + inhibitor – Plasmodium vivax<br />
-**[[6aqo]], [[6ar9]], [[6apv]], [[6apu]], [[6apt]], [[6aps]], [[5kap]], [[5k51]], [[5jsq]] - TbHGPRT + inhibitor <br />
-*Hypoxanthine-guanine phosphoribosyltransferase ternary complex
-**[[1bzy]] - hHPRT + inhibitor + guanine derivative<br />
-**[[1a95]] - EcHPRT + guanine + PRPP  derivative<br />
-**[[1a96]] - EcHPRT + xanthine + PRPP  derivative<br />
-**[[1tc2]], [[1i0i]], [[1i0l]], [[1i13]], [[1i14]] – TcHPRT + pyrimidine derivative + PRPP  derivative<br />
-**[[1p18]] - TcHPRT (mutant) + pyrimidine derivative + PRPP<BR />
-**[[1qk5]] - TgHPRT (mutant) + XMP + pyrophosphate<br />
-**[[1fsg]] - TgHPRT + guanine derivative + PRPP<BR />
-**[[1cjb]] - PfHPRT + pyrophosphate + inhibitor<br />
-**[[5knq]], [[5knp]] - MtHGPRT + pyrophosphate + nucleoside phosphonate <br />
-**[[4rhy]] - MtHGPRT + pyrophosphate + GMP<br />
-**[[6d9r]] - BaHGPRT + PRPP + deazaquanine<br />
-*'''Hypoxanthine-guanine-xanthine PRT or purine PRT'''
-**[[5bqo]] - SsHGXPRT <br />
-**[[5bqp]] - SsHGXPRT + pyrophosphate <br />
-*'''Quinolinic acid phosphoribosyltransferase'''
-**[[2jbm]], [[5ayx]], [[4kwv]] – hQAPRT<br />
-**[[3c2e]] - yQAPRT <br />
-**[[1o4u]] - TmQAPRT – ''Thermotoga maritima''<br />
-**[[1qpo]] – MtQAPRT – ''Mycobacterium tuberculosis''  <br />
-**[[5hul]] - SpQAPRT (mutant)<br />
-*Quinolinic acid phosphoribosyltransferase complex
-**[[5ayy]] - hQAPRT + quinolinic acid<br />
-**[[4kww]] – hQAPRT + phthalate <br />
-**[[5ayz]] – hQAPRT + nicotinate mononucleotide  <br />
-**[[4i9a]] – QAPRT + nicotinate mononucleotide – pig<br />
-**[[3c2o]] - yQAPRT + quinolinic acid<br />
-**[[3c2f]] - yQAPRT + PRPP<BR />
-**[[3c2r]] - yQAPRT + inhibitor<br />
-**[[3c2v]] - yQAPRT + inhibitor + PRPP<BR />
-**[[1qap]] - StQAPRT + quinolinic acid<br />
-**[[1qpr]] - MtQAPRT + PRPP  derivative <br />
-**[[1qpn]] – MtQAPRT + nicotinate mononucleotide  <br />
-**[[1qpq]] - MtQAPRT + quinolinic acid<br />
-**[[2b7n]] – HpQAPRT + quinolinic acid <br />
-**[[2b7p]] – HpQAPRT + phthalate <br />
-**[[2b7q]] – HpQAPRT + nicotinate mononucleotide  <br />
-*'''Uracil phosphoribosyltransferase'''
-**[[1w30]], [[5e38]] - MtUPRT <br />
-**[[1bd3]] - TgUPRT (mutant) <br />
-**[[1v9s]] - TtUPRT <br />
-**[[2e55]] - UPRT – ''Aquifex aeolicus'' <br />
-**[[2ehj]] - EcUPRT <br />
-**[[3dmp]] - UPRT – ''Burkholderia pseudomallei''
-*Uracil phosphoribosyltransferase complex
-**[[1upu]] - TgUPRT (mutant) + UMP<br />
-**[[1jlr]] - TgUPRT (mutant) + GTP<br />
-**[[1bd4]] - TgUPRT (mutant) + uracil<br />
-**[[1upf]] - TgUPRT (mutant) + fluorouracil<br />
-**[[1jls]] - TgUPRT (mutant) + uracil + PRPP<BR />
-**[[1i5e]], [[2igb]] - UPRT + UMP – ''Bacillus caldolyticus''<br />
-**[[1o5o]] - TmUPRT + UMP<br />
-**[[1vst]], [[3g6w]] - SsUPRT + GTP + PRPP
-*'''Adenine phosphoribosyltransferase'''
-**[[6hgp]] – hAPRT <br />
-**[[1g2p]], [[1g2q]] – yAPRT <br />
-**[[1qcc]], [[1qcd]] - LdAPRT – ''Leishmania donovani''<br />
-**[[2dy0]] - EcAPRT <br />
-**[[4lza]] – APRT – ''Thermoanaerobacter pseudethanolicus''<br />
-**[[4m0k]] – APRT – ''Rhodothermus marinus''<br />
-**[[4mb6]], [[5y4a]] – YpAPRT – ''Yersinia pseudotuberculosis''<br />
-**[[4trb]] – SsAPRT <br />
-**[[5yw2]] - FtAPRT <br />
-**[[5zgo]] - TtAPRT <br />
-*Adenine phosphoribosyltransferase complex
-**[[1ore]], [[1zn8]], [[1zn9]], [[6fcl]] - hAPRT + AMP<br />
-**[[4x44]], [[4x45]] - hAPRT (mutant) + AMP <br />
-**[[6hgr]] - hAPRT + IMP<br />
-**[[6hgs]] - hAPRT + GMP<br />
-**[[6fch]] - hHGPRT + PRPP<BR />
-**[[1zn7]], [[6fci]] - hHGPRT + adenine + PRPP<BR />
-**[[6hgq]] - hHGPRT + hypoxanthine + PRPP<BR />
-**[[6fd6]], [[6fd5]], [[6fd4]] - hHGPRT (mutant) + adenine + PRPP<BR />
-**[[5vjp]], [[5vjn]] – yAPRT1 + adenine + DIAB<br />
-**[[5yw5]] - FtAPRT + adenine<br />
-**[[1qb7]] - LdAPRT + adenine<br />
-**[[1qb8]] - LdAPRT + AMP<br />
-**[[4trc]] - SsAPRT + adenine<br />
-**[[4ts5]] - SsAPRT + AMP<br />
-**[[5b6h]] - YpAPRT + AMP <br />
-**[[5zoc]], [[5znq]], [[5zmi]], [[5zc7]] - YpAPRT + adenine <br />
-**[[5y07]] - YpHGPRT + PRPP<BR />
-**[[1mzv]] - LtAPRT + AMP<br />
-**[[4ts7]] - SsAPRT + ADP<br />
-**[[1l1q]] - GiAPRT + adenine derivative<br />
-**[[1l1r]] - GiAPRT + adenine derivative + PRPP<BR />
-*'''Nicotinate mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase'''
-**[[1l4b]] – StNN:DBI PRT <br />
-**[[4kqh]] - StNN:DBI PRT (mutant)<br />
-**[[1wx1]] – TtNN:DBI PRT <br />
-**[[3u4g]] – PhNN:DBI PRT<br />
-**[[6b5f]] – NN:DBI – ''Yersinia enterocolitica''<br />
-*Nicotinate mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase complex
-**[[1jh8]], [[4kqf]] – StNN:DBI PRT + adenine<br />
-**[[1l4e]], [[1l4f]], [[1l4g]], [[1l4h]], [[1l4k]], [[1l4l]], [[1l4m]], [[1l4n]], [[1l5f]], [[1l5k]], [[1l5l]], [[1l5m]], [[1l5n]], [[1l5o]] - StNN:DBI PRT + product-aldimine complex<br />
-**[[1jha]] – StNN:DBI PRT + AMP + nicotinate<br />
-**[[4kqi]], [[1dov]] - StNN:DBI PRT (mutant) + nicotinate + α-ribazole phosphate<br />
-**[[1jhm]] – StNN:DBI PRT + benzimidazole<br />
-**[[1jho]] – StNN:DBI PRT + NaMN + benzimidazole<br />
-**[[1jhp]], [[1d0s]] – StNN:DBI PRT + benzimidazole derivative<br />
-**[[1jhq]] - StNN:DBI PRT + NaMN + benzimidazole derivative<br />
-**[[1jhr]] - StNN:DBI PRT + NaMN + hydroxypurine<br />
-**[[1jhu]] - StNN:DBI PRT + cresol<br />
-**[[4kqk]] - StNN:DBI PRT (mutant) + cresol<br />
-**[[1jhv]] - StNN:DBI PRT + nicotinate + cresol<br />
-**[[1jhx]] - StNN:DBI PRT + phenol<br />
-**[[1jhy]] - StNN:DBI PRT + phenol + nicotinate<br />
-**[[4kqj]] - StNN:DBI PRT (mutant) + NaMN + cresol<br />
-**[[4kqg]] - StNN:DBI PRT (mutant) + cobamide<br />
-*'''Anthranilate phosphoribosyltransferase'''
-**[[1o17]] - SsANPRT <br />
-**[[1khd]] – PcANPRT – ''Pectobacterium carotovorum''<br />
-**[[1v8g]], [[2elc]] - TtANPRT <br />
-**[[1vqu]] - ANPRT – Nostoc<br />
-**[[3qr9]], [[5c2l]] – MtANPRT<br />
-**[[4x5a]] - MtANPRT (mutant) <BR />
-**[[4hkm]] - ANPRT – ''Xanthomonas campestris''<br />
-**[[4gtn]] – AcANPRT – ''Acinetobacter''<br />
-**[[5nof]], [[5noe]] – ANPRT – ''Thermococcus kodkarensis''<br />
-*Anthranilate phosphoribosyltransferase complex containing anthranilate
-**[[4owm]], [[4own]], [[4owo]], [[4owq]], [[4ows]], [[4owu]], [[4n5v]], [[4n93]] - MtANPRT + PRPP + anthranilate derivative<BR />
-**[[4ij1]], [[4m0r]], [[4owv]], [[4n8q]] - MtANPRT + anthranilate derivative <br />
-**[[4x5d]] - MtANPRT (mutant) + anthranilate<BR />
-**[[4x5e]] - MtANPRT (mutant) + anthranilate + POP<BR />
-**[[1zyk]] - SsANPRT + anthranilate + PRPP<BR />
-**[[4giu]], [[4gkm]]- PfANPRT + anthranilate derivative + PRPP<br />
-**[[4yi7]] - AcMtANPRT + anthranilate<BR />
-*Anthranilate phosphoribosyltransferase other complexes
-**[[1kgz]] - PcANPRT + PRPP<BR />
-**[[1zvw]], [[5byt]], [[5c1r]], [[5c7s]] - MtANPRT + PRPP<BR />
-**[[4x58]], [[4x59]], [[4x5b]] - MtANPRT (mutant) + PRPP<BR />
-**[[4x5c]] - MtANPRT (mutant) + PRPP + POP<BR />
-**[[1zxy]] - SsANPRT + PRPP<BR />
-**[[3gbr]] - SsANPRT (mutant) + PRPP<BR />
-**[[1gxb]] - SsANPRT + POP<br />
-**[[2gvq]] - SsANPRT + anthranilate<br />
-**[[4ztv]], [[5bne]], [[5bo2]], [[5bo3]] - MtANPRT + inhibitor <BR />
-**[[3qqs]], [[3qs8]], [[3qsa]], [[3r6c]], [[3r88]], [[3twp]], [[3uu1]], [[4zof]], [[4zoj]], [[4zok]] - MtANPRT + inhibitor + PRPP<BR />
-*'''ATP phosphoribosyltransferase''' See [[ATP Phosphoribosyl Transferase]]
-*'''Nicotinate phosphoribosyltransferase'''
-**[[4yub]] - hNIPRT <br />
-**[[1vlp]] - yNIPRT <br />
-**[[1ybe]] - NIPRT – ''Agrobacterium tumefaciens''<br />
-**[[1yir]] - NIPRT – ''Pseudomonas aeruginosa''<br />
-**[[1ytd]], [[2i1o]] - TaNIPRT – ''Thermoplasma acidophilum''<br />
-**[[2bpq]] - MtNIPRT <br />
-**[[2im5]] - NIPRT – ''Porphyromonas gingivalis''<br />
-**[[3os4]] - NIPRT – ''Yersinia pestis''<br />
-**[[4hl7]] - VcNIPRT <br />
-*Nicotinate phosphoribosyltransferase complex
-**[[1yte]] - TaNIPRT + PRPP<BR />
-**[[1ytk]] - TaNIPRT + NAMN<br />
-**[[4mzy]] – NIPRT + malonate + Pi – ''Enterococcus faecalis''<br />
-*'''Nicotinamide phosphoribosyltransferase'''
-**[[2e5b]] – hNMPRT<br />
-**[[2gvl]] - mNMPRT – mouse<br />
-**[[2h3b]] – mNMPRT (mutant) <br />
-**[[2g95]] - NMPRT - rat<br />
-*Nicotinamide phosphoribosyltransferase complex
-**[[2gvg]] - hNMPRT + NMN<BR />
-**[[2g97]], [[3g8e]] - rNMPRT + FK-866<br />
-**[[2gvj]] - hNMPRT + FK-866<br />
-**[[2e5c]] - hNMPRT + PRPP<BR />
-**[[2e5d]] - hNMPRT + nicotinamide<br />
-**[[3dgr]] - hNMPRT + ADP analog<br />
-**[[4jnm]], [[4jr5]], [[4kfn]], [[4kfo]], [[4kfp]], [[4lts]], [[4lv9]], [[4lva]], [[4lvb]], [[4lvd]], [[4lvf]], [[4lvg]], [[4lww]], [[4m6p]], [[4m6q]], [[4n9b]], [[4n9c]], [[4n9d]], [[4n9e]], [[4l4l]], [[4l4m]], [[4o0z]], [[4o10]], [[4o12]], [[4o13]], [[4o14]], [[4o15]], [[4o16]], [[4o17]], [[4o18]], [[4o19]], [[4o1a]], [[4o1b]], [[4o1c]], [[4o1d]], [[4wq6]], [[4o28]], [[5kit]], [[5u2m]], [[5u2n]], [[5upe]], [[5upf]], [[6e68]], [[5wi1]], [[5wi0]], [[6b76]], [[6b75]], [[6atb]] - hNMPRT + inhibitor<br />
-**[[3dhd]], [[3dhf]] - hNMPRT + pyrophosphate + NMN<BR />
-**[[3dkj]], [[3dkl]] - hNMPRT + benzamide + PRPP<BR />
-**[[5nsd]], [[5lx5]], [[5lx3]] - hNMPRT + piperidine derivative<br />
-**[[2h3d]] - mNMPRT + NMN<BR />
-**[[2g96]] - rNMPRT + NMN<BR />
-**[[2g97]], [[3g8e]] - rNMPRT + FK-866<br />
-}}
 == References ==
 <references/>
 [[Category:Topic Page]]