190d

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{{STRUCTURE_190d| PDB=190d | SCENE= }}
{{STRUCTURE_190d| PDB=190d | SCENE= }}
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'''CRYSTAL STRUCTURE OF A FOUR-STRANDED INTERCALATED DNA: D(C4)'''
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===CRYSTAL STRUCTURE OF A FOUR-STRANDED INTERCALATED DNA: D(C4)===
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==Overview==
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The crystal structure of d(C4) solved at 2.3-A resolution reveals a four-stranded molecule composed of two interdigitated or intercalated duplexes. The duplexes are held together by hemiprotonated cytosine-cytosine base pairs and are parallel stranded, but the two duplexes point in opposite directions. The molecule has a slow right-handed twist of 12.4 degrees between covalently linked cytosine base pairs, and the base stacking distance is 3.1 A. This is in general agreement with the NMR studies. A biological role for DNA in this conformation is suggested.
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The line below this paragraph, {{ABSTRACT_PUBMED_7947764}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7947764 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7947764}}
==About this Structure==
==About this Structure==
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[[Category: Quadruple helix]]
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[[Category: U-dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:34:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:39:12 2008''

Revision as of 12:39, 30 June 2008

Image:190d.png

Template:STRUCTURE 190d

CRYSTAL STRUCTURE OF A FOUR-STRANDED INTERCALATED DNA: D(C4)

Template:ABSTRACT PUBMED 7947764

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of a four-stranded intercalated DNA: d(C4)., Chen L, Cai L, Zhang X, Rich A, Biochemistry. 1994 Nov 22;33(46):13540-6. PMID:7947764

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