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1914

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{{STRUCTURE_1914| PDB=1914 | SCENE= }}
{{STRUCTURE_1914| PDB=1914 | SCENE= }}
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'''SIGNAL RECOGNITION PARTICLE ALU RNA BINDING HETERODIMER, SRP9/14'''
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===SIGNAL RECOGNITION PARTICLE ALU RNA BINDING HETERODIMER, SRP9/14===
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==Overview==
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The mammalian signal recognition particle (SRP) is an 11S cytoplasmic ribonucleoprotein that plays an essential role in protein sorting. SRP recognizes the signal sequence of the nascent polypeptide chain emerging from the ribosome, and targets the ribosome-nascent chain-SRP complex to the rough endoplasmic reticulum. The SRP consists of six polypeptides (SRP9, SRP14, SRP19, SRP54, SRP68 and SRP72) and a single 300 nucleotide RNA molecule. SRP9 and SRP14 proteins form a heterodimer that binds to the Alu domain of SRP RNA which is responsible for translation arrest. We report the first crystal structure of a mammalian SRP protein, that of the mouse SRP9/14 heterodimer, determined at 2.5 A resolution. SRP9 and SRP14 are found to be structurally homologous, containing the same alpha-beta-beta-beta-alpha fold. This we designate the Alu binding module (Alu bm), an additional member of the family of small alpha/beta RNA binding domains. The heterodimer has pseudo 2-fold symmetry and is saddle like, comprising a strongly curved six-stranded amphipathic beta-sheet with the four helices packed on the convex side and the exposed concave surface being lined with positively charged residues.
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The line below this paragraph, {{ABSTRACT_PUBMED_9233785}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9233785 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9233785}}
==About this Structure==
==About this Structure==
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[[Category: Rna binding]]
[[Category: Rna binding]]
[[Category: Translation regulation]]
[[Category: Translation regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:34:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:39:15 2008''

Revision as of 12:39, 30 June 2008

Image:1914.png

Template:STRUCTURE 1914

SIGNAL RECOGNITION PARTICLE ALU RNA BINDING HETERODIMER, SRP9/14

Template:ABSTRACT PUBMED 9233785

About this Structure

1914 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

The crystal structure of the signal recognition particle Alu RNA binding heterodimer, SRP9/14., Birse DE, Kapp U, Strub K, Cusack S, Aberg A, EMBO J. 1997 Jul 1;16(13):3757-66. PMID:9233785

Page seeded by OCA on Mon Jun 30 15:39:15 2008

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