6bse

<table><tr><td colspan='2'>[[6bse]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Cotton-top_tamarin Cotton-top tamarin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BSE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BSE FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NR3C1, GRL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9490 Cotton-top tamarin])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bse FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bse OCA], [http://pdbe.org/6bse PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bse RCSB], [http://www.ebi.ac.uk/pdbsum/6bse PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bse ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/GCR_SAGOE GCR_SAGOE]] Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Mediates glucocorticoid-induced apoptosis. Promotes accurate chromosome segregation during mitosis. May act as a tumor suppressor. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression.[UniProtKB:P04150][UniProtKB:P06537]

[[Category: Cotton-top tamarin]]

[[Category: Pufall, M A]]

[[Category: Gene regulation]]

[[Category: Glucocorticoid receptor gene expression protein:dna binding]]