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1qnx

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Revision as of 09:59, 15 September 2021

Ves v 5, an allergen from Vespula vulgaris venom

Structural highlights

1qnx is a 1 chain structure with sequence from Paravespula vulgaris. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Ves v 5 is one of three major allergens found in yellow-jacket venom: phospholipase A(1) (Ves v 1), hyaluronidase (Ves v 2), and antigen 5 (Ves v 5). Ves v 5 is related by high amino acid sequence identity to pathogenesis-related proteins including proteins from mammals, reptiles, insects, fungi, and plants. The crystal structure of Ves v 5 has been solved and refined to a resolution of 1.9 A. The majority of residues conserved between the pathogenesis-related proteins can be rationalized in terms of hydrogen bonding patterns and hydrophobic interactions defining an alpha-beta-alpha sandwich core structure. A small number of consensus residues are solvent exposed (including two adjacent histidines) and located in an elongated cavity that forms a putative active site. The site has no structural resemblance to previously characterized enzymes. Homologous antigen 5's from a large number of different yellow jackets, hornets, and paper wasps are known and patients show varying extents of cross-reactivity to the related antigen 5's. The structure of Ves v 5 allows a detailed analysis of the epitopes that may participate in antigenic cross-reactivity, findings that are useful for the development of a vaccine for treatment of insect allergy.

Major venom allergen of yellow jackets, Ves v 5: structural characterization of a pathogenesis-related protein superfamily.,Henriksen A, King TP, Mirza O, Monsalve RI, Meno K, Ipsen H, Larsen JN, Gajhede M, Spangfort MD Proteins. 2001 Dec 1;45(4):438-48. PMID:11746691^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Henriksen A, King TP, Mirza O, Monsalve RI, Meno K, Ipsen H, Larsen JN, Gajhede M, Spangfort MD. Major venom allergen of yellow jackets, Ves v 5: structural characterization of a pathogenesis-related protein superfamily. Proteins. 2001 Dec 1;45(4):438-48. PMID:11746691

1 Structural highlights
2 Evolutionary Conservation
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1qnx"

@@ Line 3: / Line 3: @@
 <StructureSection load='1qnx' size='340' side='right'caption='[[1qnx]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1qnx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Paravespula_vulgaris Paravespula vulgaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QNX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QNX FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1qnx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Paravespula_vulgaris Paravespula vulgaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QNX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QNX FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qnx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qnx OCA], [http://pdbe.org/1qnx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qnx RCSB], [http://www.ebi.ac.uk/pdbsum/1qnx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1qnx ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qnx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qnx OCA], [https://pdbe.org/1qnx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qnx RCSB], [https://www.ebi.ac.uk/pdbsum/1qnx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qnx ProSAT]</span></td></tr>
 </table>
 == Evolutionary Conservation ==

1qnx

From Proteopedia

Revision as of 09:59, 15 September 2021

Ves v 5, an allergen from Vespula vulgaris venom

Structural highlights

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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