1pil

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<StructureSection load='1pil' size='340' side='right'caption='[[1pil]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='1pil' size='340' side='right'caption='[[1pil]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1pil]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PIL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1pil]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PIL FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pil FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pil OCA], [http://pdbe.org/1pil PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pil RCSB], [http://www.ebi.ac.uk/pdbsum/1pil PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1pil ProSAT]</span></td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pil FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pil OCA], [https://pdbe.org/1pil PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pil RCSB], [https://www.ebi.ac.uk/pdbsum/1pil PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pil ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GLNB_ECOLI GLNB_ECOLI]] P-II indirectly controls the transcription of the glutamine synthetase gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of GlnA. When P-II is uridylylated to P-II-UMP, these events are reversed. When the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylation of glutamine synthetase by GlnE, so activating the enzyme.
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[[https://www.uniprot.org/uniprot/GLNB_ECOLI GLNB_ECOLI]] P-II indirectly controls the transcription of the glutamine synthetase gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of GlnA. When P-II is uridylylated to P-II-UMP, these events are reversed. When the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylation of glutamine synthetase by GlnE, so activating the enzyme.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

Revision as of 09:30, 8 September 2021

STRUCTURE OF THE ESCHERICHIA COLI SIGNAL TRANSDUCING PROTEIN PII

PDB ID 1pil

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