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== Structure == | == Structure == | ||
| - | The structure of the <scene name='78/781196/Tata_binding_protein/1'>TATA-Binding Protein (TBP)</scene> has a pseudo-symmetry within its structure which contains two 88-amino acid repeats. The <scene name='78/781196/Tata-binding_protein/1'>secondary structures</scene> of this protein include both Alpha and Beta components on the distribution of the symmetry. This structure attaches to a DNA structure of deformity in the helix; the deformity is for the purpose of binding. The DNA structure's <scene name='78/781196/Inner_connections/1'>inner connections</scene> show the minor groove is wide open to have complete access for the TBP to bind within it (2). | + | The structure of the <scene name='78/781196/Tata_binding_protein/1'>TATA-Binding Protein (TBP)</scene> has a pseudo-symmetry within its structure which contains two 88-amino acid repeats. The <scene name='78/781196/Tata-binding_protein/1'>secondary structures</scene> of this protein include both Alpha and Beta components on the distribution of the symmetry. This structure attaches to a DNA structure of deformity in the helix; the deformity is for the purpose of binding. The DNA structure's <scene name='78/781196/Inner_connections/1'>inner connections</scene> show the minor groove is wide open to have complete access for the TBP to bind within it (2). Some interactions are with the minor groove, and some interactions are with the sugar/ phosphate helix within the backbone. |
Revision as of 03:17, 28 November 2019
TATA-Binding Protein (TBP)
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References
1. Imbalzano, A., Kwon, H., Green, M. et al. Facilitated binding of TATA-binding protein to nucleosomal DNA. Nature 370, 481–485 (1994) doi:10.1038/370481a0
2. Juo, Zong Sean, et al. “How Proteins Recognize the TATA Box.” Journal of Molecular Biology, vol. 261, no. 2, 1996, pp. 239–254., doi:10.1006/jmbi.1996.0456.
3. Kim, J., & Iyer, V. R. (2004). Global role of TATA box-binding protein recruitment to promoters in mediating gene expression profiles. Molecular and cellular biology, 24(18), 8104–8112. doi:10.1128/MCB.24.18.8104-8112.2004
