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Protein kinase C

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*'''Atypical PKC'''
*'''Atypical PKC'''
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*PKC-ι
+
*PKC-ι; domains – PB1 16-99; kinase 249-588
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**[[1vd2]] – hAPKC-ι PB1 domain – NMR
+
**[[1vd2]] – hAPKC-ι PB1 domain – NMR<br />
-
 
+
**[[1wmh]] - hAPKC-ι PB1 domain + PAR6 alpha<br />
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**[[1zrz]] - hAPKC-ι catalytic domain
+
**[[3a8w]], [[3a8x]], [[1zrz]] - hAPKC-ι kinase domain<br />
-
 
+
**[[6ilz]] - hAPKC-ι kinase domain + inhibitor<br />
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**[[3a8w]], [[3a8x]] - hAPKC-ι kinase domain<br />
+
**[[3zh8]] - hAPKC-ι kinase domain (mutant) + inhibitor<br />
**[[3zh8]] - hAPKC-ι kinase domain (mutant) + inhibitor<br />
**[[1wmh]] - hAPKC-ι PB1 domain + PAR6 alpha<br />
**[[1wmh]] - hAPKC-ι PB1 domain + PAR6 alpha<br />
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**[[4dc2]] - hAPKC-ι residues 231-595 + PAR3 peptide<br />
+
**[[4dc2]] - hAPKC-ι kinase domain + PAR3 peptide<br />
**[[5lih]] - hAPKC-ι kinase domain + PKC-εζ peptide<br />
**[[5lih]] - hAPKC-ι kinase domain + PKC-εζ peptide<br />

Revision as of 07:37, 1 December 2019

Rat protein kinase α C2 domain complex with phosphatidylinositol, phosphate and Ca+2 ion (green), 3gpe

Drag the structure with the mouse to rotate

3D structures of protein kinase C

Updated on 01-December-2019

References

  1. ↑ Idris I, Gray S, Donnelly R. Protein kinase C activation: isozyme-specific effects on metabolism and cardiovascular complications in diabetes. Diabetologia. 2001 Jun;44(6):659-73. PMID:11440359 doi:http://dx.doi.org/10.1007/s001250051675
  2. ↑ Koya D, King GL. Protein kinase C activation and the development of diabetic complications. Diabetes. 1998 Jun;47(6):859-66. PMID:9604860
  3. ↑ Koivunen J, Aaltonen V, Peltonen J. Protein kinase C (PKC) family in cancer progression. Cancer Lett. 2006 Apr 8;235(1):1-10. PMID:15907369 doi:http://dx.doi.org/10.1016/j.canlet.2005.03.033
  4. ↑ Guerrero-Valero M, Ferrer-Orta C, Querol-Audi J, Marin-Vicente C, Fita I, Gomez-Fernandez JC, Verdaguer N, Corbalan-Garcia S. Structural and mechanistic insights into the association of PKC{alpha}-C2 domain to PtdIns(4,5)P2. Proc Natl Acad Sci U S A. 2009 Apr 3. PMID:19346474

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky

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