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From Proteopedia
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==Nitrate Transporter== | ==Nitrate Transporter== | ||
<StructureSection load='4IU9' size='340' side='right' caption='Nitrate Transporter=''> | <StructureSection load='4IU9' size='340' side='right' caption='Nitrate Transporter=''> | ||
| - | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:23523348</ref> to the rescue. | ||
Nitrate Transporter is a protein compound found in bacteria, specifically Escherichia coli <ref>PMID:11967075</ref>.This protein compound is a complex made up of NarK and NarU. | Nitrate Transporter is a protein compound found in bacteria, specifically Escherichia coli <ref>PMID:11967075</ref>.This protein compound is a complex made up of NarK and NarU. | ||
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== Function == | == Function == | ||
| - | The Nitrate Transporter complex is active in regulation of nitrogen in the bacteria cell <ref>PMID:23523348</ref>. The | + | The Nitrate Transporter complex is active in regulation of nitrogen in the bacteria cell <ref>PMID:23523348</ref>. The complex is expected to provide both nitrate and nitrite transport mechanisms <ref>PMID:11967075</ref>. This transport of Nitrate is under speculation of being different than the typical canonical rocker-switch model<ref>PMID:23523348</ref>. On the NarU portion, Arg87, Arg303, As173, and Tyr261 are four amino acids that have solid electron density and seems to have functional importance. NarK does not seem to have the same electron density for an obvious binding site. In NarU, the transport mechanism was severely hindered when these amino acid sites were mutated. And when the amino acids were mutated, the binding site was prevented by the mutation from completing its function. |
== Disease == | == Disease == | ||
Revision as of 15:47, 30 November 2019
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Nitrate Transporter
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References
- ↑ Clegg S, Yu F, Griffiths L, Cole JA. The roles of the polytopic membrane proteins NarK, NarU and NirC in Escherichia coli K-12: two nitrate and three nitrite transporters. Mol Microbiol. 2002 Apr;44(1):143-55. doi: 10.1046/j.1365-2958.2002.02858.x. PMID:11967075 doi:http://dx.doi.org/10.1046/j.1365-2958.2002.02858.x
- ↑ Yan H, Huang W, Yan C, Gong X, Jiang S, Zhao Y, Wang J, Shi Y. Structure and mechanism of a nitrate transporter. Cell Rep. 2013 Mar 28;3(3):716-23. doi: 10.1016/j.celrep.2013.03.007. Epub 2013, Mar 21. PMID:23523348 doi:http://dx.doi.org/10.1016/j.celrep.2013.03.007
- ↑ Clegg S, Yu F, Griffiths L, Cole JA. The roles of the polytopic membrane proteins NarK, NarU and NirC in Escherichia coli K-12: two nitrate and three nitrite transporters. Mol Microbiol. 2002 Apr;44(1):143-55. doi: 10.1046/j.1365-2958.2002.02858.x. PMID:11967075 doi:http://dx.doi.org/10.1046/j.1365-2958.2002.02858.x
- ↑ Yan H, Huang W, Yan C, Gong X, Jiang S, Zhao Y, Wang J, Shi Y. Structure and mechanism of a nitrate transporter. Cell Rep. 2013 Mar 28;3(3):716-23. doi: 10.1016/j.celrep.2013.03.007. Epub 2013, Mar 21. PMID:23523348 doi:http://dx.doi.org/10.1016/j.celrep.2013.03.007
- ↑ Brons HJ, Zehnder AJ. Aerobic nitrate and nitrite reduction in continuous cultures of Escherichia coli E4. Arch Microbiol. 1990;153(6):531-6. doi: 10.1007/bf00245261. PMID:2196029 doi:http://dx.doi.org/10.1007/bf00245261
